Figure 3.

The time course of biomarkers of thrombin generation and fibrinolysis in placebo-treated patients with severe sepsis in the PROWESS study are shown here as means and 95% confidence intervals, using standard error of the mean and repeated measures analysis without imputing for missing data. The number of observations for each time point appears below the x-axis for (●) survivors and (○) nonsurvivors. *P < 0.05 versus nonsurvivors. F1.2, prothrombin fragment 1.2; PAI, plasminogen activator inhibitor; TAFI, thrombin-activatable fibinolysis inhibitor; TAT, thrombin–antithrombin complex.