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Median biomarker levels at baseline by quartile of Acute Physiology and Chronic Health Evaluation II score (n = 1690) |
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| Biomarker |
1st Quartile (median [95% CI]) |
2nd Quartile (median [95% CI]) |
3rd Quartile (median [95% CI]) |
4th Quartile (median [95% CI]) |
ρ |
P |
|
|
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| D-dimer (μg/ml) |
3.84 (3.60–4.24) |
3.93 (3.59–4.61) |
4.11 (3.49–5.03) |
5.03 (4.41–5.56) |
0.10 |
<0.001a |
| IL-6 (pg/ml) |
289 (245–369) |
384 (322–489) |
623 (494–829) |
1043 (809–1613) |
0.23 |
<0.001 |
| Protein C (%) |
0.52 (0.49–0.55) |
0.48 (0.45–0.51) |
0.50 (0.44–0.53) |
0.42 (0.40–0.45) |
-0.12 |
<0.001a |
| AT (%) |
0.62 (0.60–0.65) |
0.59 (0.57–0.62) |
0.60 (0.57–0.63) |
0.55 (0.53–0.57) |
-0.11 |
<0.001 |
| Protein S (%) |
0.42 (0.36–0.47) |
0.37 (0.33–0.41) |
0.38 (0.33–0.46) |
0.33 (0.30–0.35) |
-0.07 |
0.006a |
| PT (seconds) |
18.1 (17.6–18.4) |
18.5 (18.0–19.0) |
18.6 (18.2–19.0) |
19.7 (19.1–20.1) |
0.15 |
<0.001 |
| APTT (seconds) |
40.5 (39.9–42.3) |
42.5 (40.9–43.9) |
42.5 (40.3–43.6) |
45.1 (43.4–46.4) |
0.13 |
<0.001 |
| Platelets (109/l) |
184 (173–192) |
182 (167–191) |
185 (174–199) |
179 (167–192) |
-0.03 |
0.19 |
| F1.2 (nmol/l) |
1.65 (1.38–1.87) |
1.83 (1.49–2.19) |
2.09 (1.67–2.38) |
1.60 (1.38–1.91) |
0.04 |
0.49b |
| TAT (μg/l) |
10.7 (9.3–13.8) |
10.8 (9.1–13.4) |
11.7 (10.1–16.3) |
12.3 (9.9–14.8) |
0.06 |
0.27 |
| PAI-1 (AU/ml) |
25 (21.0–33.0) |
33 (28–38) |
34 (26–40) |
40 (36–55) |
0.24 |
<0.001 |
| TAFI (μg/ml) |
4.4 (3.7–4.9) |
4.3 (3.7–4.8) |
4.5 (4.1–5.3) |
5.4 (4.5–6.1) |
0.12 |
0.03a |
| α2-AP (%) |
103 (93–106) |
93 (90–105) |
96 (90–113) |
95 (88–105) |
-0.04 |
0.43 |
| Plasminogen (%) |
62.0 (57–69) |
59.5 (52–65) |
60.5 (58–67) |
60.0 (55–70) |
0.004 |
0.94 |
| sTM (ng/ml) |
61 (56–71) |
62 (52–75) |
83 (73–109) |
91 (74–117) |
0.29 |
<0.001 |
| IL-1β (pg/ml) |
≤10 (10–10) |
≤10 (10–10) |
≤10 (10–10) |
≤10 (10–10) |
0.06 |
0.26 |
| IL-10 (pg/ml) |
≤10 (10–10) |
≤10 (10–10) |
≤10 (10–30) |
≤10 (10–27) |
0.16 |
0.001 |
| IL-8 (pg/ml) |
50 (50–50) |
50 (50–50) |
50 (50–144) |
117 (50–177) |
0.21 |
<0.001 |
| TNF-α (pg/ml) |
≤10 (10–21) |
22 (10–27) |
21 (10–41) |
28 (21–33) |
0.17 |
0.005 |
|
The quartiles of Acute Physiology and Chronic Health Evaluation (APACHE) II scores are as follows: 1st quartile, score 3–19; 2nd quartile, score 20–24; 3rd quartile, score 25–29; and 4th quartile, score 30–53. Spearman rank correlation (ρ) is between continuous values of APACHE with each biomarker. aNonsignificant correlation with APACHE if 4th quartile is deleted. bSignificant correlation with APACHE if 4th quartile is deleted. α2-AP, α2-antiplasmin; APTT, activated partial thromboplastin time; AT, antithrombin; CI, confidence interval; F1.2, prothrombin fragment 1.2; IL, interleukin; PAI, plasminogen activator inhibitor; PT, prothrombin time; TAFI, thrombin-activatable fibrinolysis inhibitor; sTM, soluble thrombomodulin; TAT, thrombin–antithrombin complex; TNF, tumor necrosis factor. | ||||||
Kinasewitz et al. Critical Care 2004 8:R82 |
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