Table 1

Central venous and pulmonary artery occluded pressures, systemic oxygen-derived variables, arterial lactate, pH and hemoglobin
Parameter
 Baseline
 Minutes after bacterial infusion




15
 90
 120
 150
CVP (mmHg)
     Control
 3.7 ± 0.4
 4.0 ± 0.4
 2.7 ± 0.5
 2.4 ± 0.5
 2.7 ± 0.5
     Lactated Ringer's
 3.3 ± 0.5
 2.8 ± 0.5
 2.4 ± 0.5
 4.2 ± 0.8
 4.9 ± 0.8
PAOP (mmHg)
     Control
 6.1 ± 0.5
 5.3 ± 0.8
 4.0 ± 0.5
 4.2 ± 0.6
 4.3 ± 0.6
     Lactated Ringer's
 4.4 ± 0.5
 4.1 ± 0.6
 4.4 ± 0.6
 5.0 ± 0.7
 4.9 ± 0.5
pH
     Control
 7.416 ± 0.01
 7.416 ± 0.01
 7.416 ± 0.01
 7.416 ± 0.01
 7.416 ± 0.01
     Lactated Ringer's
 7.424 ± 0.01
 7.406 ± 0.01
 7.384 ± 0.01
 7.384 ± 0.01
 7.408 ± 0.01
Hemoglobin (g/dl)
     Control
 12.2 ± 0.5
 12.5 ± 0.5
 13.7 ± 0.3
 14.0 ± 0.3*‡
 14.2 ± 0.4*‡
     Lactated Ringer's
 12.6 ± 0.4
 12.8 ± 0.5
 13.8 ± 0.5
 12.1 ± 0.5
 11.5 ± 0.6
DO2 (ml/min)
     Control
 402.6 ± 27.3
 284.9 ± 25.1*
 321.7 ± 36.7*
 328.7 ± 37*
 325.3 ± 28.4*
     Lactated Ringer's
 432.8 ± 30.7
 322.3 ± 25.1†
 320.9 ± 29.4†
 404.5 ± 21.8
 395.4 ± 28.3
O2ER (%)
     Control
 23.9 ± 2.1
 30.5 ± 2.5*
 33.1 ± 3.0*
 28.8 ± 2.8*
 32.5 ± 2.8*
     Lactated Ringer's
 23.8 ± 3.0
 26.9 ± 3.7
 33.1 ± 5.6†
 26.7 ± 2.5
 23.3 ± 2.3‡
SVO2 (%)
     Control
 80.1 ± 2.3
 69.7 ± 2.5*
 67.4 ± 3.4*
 71.6 ± 3.2*
 67.6 ± 3.0*
     Lactated Ringer's
 78.6 ± 3.2
 73.6 ± 3.8†
 66.8 ± 5.7†
 76.7 ± 2.6†
 77.2 ± 2.3‡
Arterial lactate (mmol/l)
     Control
 1.58 ± 0.49
 1.62 ± 0.39
 3.73 ± 0.34*
 3.48 ± 0.29*
 3.31 ± 0.25*
     Lactated Ringer's
 1.57 ± 0.24
 1.85 ± 0.23
 4.01 ± 0.65†
 4.22 ± 0.59†
 3.44 ± 0.51†
Veno-arterial PCO2 gradient (mmHg)
     Control
 4.9 ± 1.0
 8.4 ± 1.2
 12.6 ± 2.0*
 9.3 ± 1.7*
 9.8 ± 2.0*
     Lactated Ringer's
 6.9 ± 1.0
 8.8 ± 1.5
 9.7 ± 1.5
 5.8 ± 1.2
 6.2 ± 0.8

Measurements were taken in control animals (n = 13) and animals treated with lactated Ringer's solution (n = 14). Data are expressed as mean ± standard error of the mean. CVP, central venous pressure; DO2, systemic oxygen delivery; O2ER, systemic oxygen extraction ratio; PAOP, pulmonary artery occluded pressure; PCO2, carbon dioxide tension; SVO2, mixed venous oxygen saturation. *P < 0.05, control versus baseline; †P < 0.05 lactated Ringer's versus baseline; ‡P < 0.05 control versus lactated Ringer's.

Lagoa et al. Critical Care 2004 8:R221   doi:10.1186/cc2871