Table 2

Regional oxygen-derived variables and portal vein lactate

Parameter

Baseline

Minutes after bacterial infusion

15

90

120

150

Mesenteric DO₂ (ml/min)

Control

71.6 ± 8.5

37.7 ± 3.9*

54.4 ± 9.6*

61.7 ± 10.6

66.6 ± 11.2

Lactated Ringer's

74.3 ± 9.1

53.5 ± 7.1^†

37.9 ± 5.2^†

47.8 ± 4.2^†

48.2 ± 4.7^†

Mesenteric O₂ER (%)

Control

15.1 ± 1.8

23.6 ± 3.1*

32.7 ± 3.7*

29.7 ± 4.5*

28.3 ± 3.5*

Lactated Ringer's

15.6 ± 2.8

19.8 ± 2.6^†

27.9 ± 2.8^†

22.3 ± 2.1^†

24.5 ± 2.3^†

SpO₂ (%)

Control

88.3 ± 1.6

75.9 ± 3.1*

67.5 ± 3.9*

71.9 ± 4.8*

71.7 ± 3.4*

Lactated Ringer's

87.9 ± 2.1

80.2 ± 1.9^†

72.4 ± 3.3^†

80.5 ± 2.1^†

77.4 ± 2.2^†

Portal vein lactate (mmol/l)

Control

1.56 ± 0.44

1.67 ± 0.37*

3.65 ± 0.32*

3.31 ± 0.35*

3.32 ± 0.28*

Lactated Ringer's

1.58 ± 0.21

1.88 ± 0.22^†

3.97 ± 0.54^†

4.01 ± 0.52^†

3.55 ± 0.44^†

Portal–arterial PCO₂ gradient (mmHg)

Control

3.6 ± 1.0

7.9 ± 1.4*

11.1 ± 1.2*

9.3 ± 2.1*

9.6 ± 1.4*

Lactated Ringer's

4.9 ± 0.9

8.7 ± 1.4^†

11.1 ± 1.6^†

6.7 ± 1.7^†

7.5 ± 1.2^†

Measurements were taken in control animals (n = 13) and animals treated with lactated Ringer's solution (n = 14). Data are expressed as mean ± standard error of the mean. DO₂, oxygen delivery; O₂ER, oxygen extraction ratio; PCO₂, carbon dioxide tension; SpO₂, portal vein oxygen saturation. *P < 0.05, control versus baseline; ^†P < 0.05 lactated Ringer's versus baseline.

Lagoa et al. Critical Care 2004 8:R221   doi:10.1186/cc2871