Table 1

Procalcitonin (PCT), C-reactive protein (CRP), lactate and sepsis score values at different categories of the sequential organ failure assessment (SOFA) score and severity of systemic inflammation according to American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) criteria

SOFA
 PCT (ng/ml)
 CRP (mg/l)
 Lactate (mmol/l)
 Sepsis score
Category of SOFA score (number of observations)
     1–6 (n = 557)
 3 (2/5)
 0.37 (0.12/1.2)
 101 (53/161)
 1.24 (0.96/1.6)
 6 (3/10)
     7–12 (n = 156)
 9 (7/10)
 2.55 (0.85/9.95)
 140 (65/209)
 1.74 (1.2/2.43)
 13 (10/16)
     13–18 (n = 31)
 14 (13/15)
 8.5 (3.3/28.4)
 180 (115/219)
 3 (2.34/3.83)
 21.5 (16.25/25.75)
     19–24 (n = 13)
 19.5 (19/20)
 23.24 (2.28/50.92)
 154 (9.6/308)
 3.7 (3.5/5)
 25(24.25/25.75)
Category according to ACCP/SCCM criteria (number of patients)
     No SIRS (n = 15)
 3 (2–4.5)
 0.14 (0.07–0.29)
 72 (20–125)
 1.26 (0.64–1.38)
 3 (0–5.5)
     SIRS (n = 15)
 4 (2.25–8.25)
 0.38 (0.16–0.93)*
 51 (19.5–80.5)
 2.13 (1.14–2.93)*
 3.5 (2–8.25)
     Sepsis/SS (n = 71)
 6 (4–9)
 3 (1.48–15.26)**
 164 (75–222)**
 2.2 (1.27–3.74)
 11 (7–17)**
     Sepsis (n = 34)
 4.5 (3–6)
 1.58 (0.41–3) **
 150 (71–209)**
 1.37 (1–2.61)
 8.5 (3.75–12.25)**
     Severe sepsis (n = 22)
 7 (6–8.25)†
 5.58 (1.84–32.93)†
 159 (75–209)
 2.19 (1.73–2.93)
 14.5 (9.25–19.75)†
     Septic shock (n = 15)
 11 (9–15)d
 13.1 (6.1–42.2)‡
 195 (75–272)
 3.7 (2.6–6.4)‡
 15 (13.5–19.5)
Trauma patients (n = 49)
 5 (3–8)
 1.4 (0.3–5.1)
 40 (16–150)
 2.7 (1.7–5)
 3 (0–5.3)

All patient groups without trauma were evaluated. Trauma patients were in a separate group. Data presented as median values (lower and upper quartiles). SIRS, systemic inflammatory response syndrome. * P < 0.05 versus no systemic inflammatory response syndrome (No-SIRS), ** P < 0.05 versus SIRS, † P < 0.05 versus sepsis, ‡ P < 0.05 versus severe sepsis.

Castelli et al. Critical Care 2004 8:R234   doi:10.1186/cc2877