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Procalcitonin (PCT), C-reactive protein (CRP), and lactate plasma levels at various severities of organ dysfunction, categorised according to four groups of the sequential organ failure assessment (SOFA) score, comparing patients with and without infection and trauma |
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| Category of SOFA score (number of observations, noninfected/infected) |
Noninfected |
Infected |
P, noninfected /infected |
Trauma (number of trauma observations) |
|
|
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| PCT (ng/ml) |
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| 1–6 (n = 180/377) |
0.14 (0.08/0.33) |
0.62 (0.24/2.12) |
< 0.001 |
0.25 (0.08–0.9) (n = 368) |
| 7–12 (n = 24/132) |
0.25 (0.2/0.3) |
2.43 (1.2/8.68) |
< 0.001 |
5.54 (0.86–12.87) (n = 88) |
| 13–18 (n = 1/30) |
0.41 |
8.5 (3.39/29.59) |
n.s. |
54 (15.58–122.4) (n = 9) |
| 19–24 (n = 0/13) |
- |
23.24 (2.28/50.9) |
- |
- |
| Pearson's correlation |
0.108 (P = n.s.) |
0.247 (P < 0.001) |
0.465 (P <0.001) |
|
| Regression, y = a + bx |
0.27 + 0.02 × SOFA score |
-0.84 + 1.526 × SOFA score |
< 0.02 |
-5 + 2.16 × SOFA score |
| CRP (mg/l) |
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| 1–6 (n = 180/377) |
68 (28/121) |
121 (68/176) |
< 0.001 |
91 (49.8–148) (n = 368) |
| 7–12 (n = 24/132) |
47(15/81) |
181 (78/271) |
< 0.001 |
110 (64–151) (n = 88) |
| 13–18 (n = 1/30) |
12.3 |
183 (128/219) |
n.s. |
94 (n = 9) |
| 19–24 (n = 0/13) |
- |
154 (9.6/308) |
- |
- |
| Pearson's correlation |
0.069 (P = n.s.) |
0.286 (P < 0.001) |
0.095 (P = n.s.) |
|
| Regression, y = a + bx |
84.53 - 0.19 × SOFA score |
105.58 + 0.72 × SOFA score |
< 0.001 |
95 + 0.24 × SOFA score |
| Lactate (mmol/l) |
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| 1–6 (n = 180/377) |
1.21 (0.96/1.44) |
1.3 (1.04/1.69) |
n.s. |
1.1 (0.86–1.51) (n = 368) |
| 7–12 (n = 24/132) |
1.55 (1.22/3.54) |
1.69 (1.2/2.2) |
n.s. |
2.09(1.19–2.61) (n = 88) |
| 13–18 (n = 1/30) |
2.8 |
3.07 (2.25/3.59) |
n.s. |
5.58 (n = 9) |
| 19–24 (n = 0/13) |
- |
3.69 (3.52/5) |
- |
- |
| Pearson's correlation |
0.350 (P < 0.002) |
0.382 (P < 0.001) |
0.431 (P <0.001) |
|
| Regression, y = a + bx |
0.918 + 0.14 × SOFA score |
0.968 + 0.12 × SOFA score |
n.s. |
0.516 + 0.235 × SOFA score |
|
Data presented as median values (lower and upper quartiles). P value from Mann–Whitney U-test. | ||||
Castelli et al. Critical Care 2004 8:R234 doi:10.1186/cc2877 |
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