Table 2

Candidate genes in acute lung injury

Gene Ontology

PubMatrix terms

Encoded protein

Gene symbol

NR

IM

CT

IN

BC

Lung

Lung injury

Interleukin-1ß

IL1B

×

×

×

1536

287

Interleukin-6

IL6

×

963

173

Tissue factor precursor

TF

×

×

411

54

Plasminogen activator inhibitor-1

PAI1

×

201

31

Cyclo-oxygenase-2

COX2

×

257

28

Interleukin-13

IL13

×

×

327

21

Vitronectin

?VNT

×

138

11

Macrophage stimulatory protein

?MSP

×

102

11

Plasminogen activator, urokinase receptor

PLAUR

×

×

83

8

Tissue-type plasminogen activator

PLAT

×

101

7

Fibrinogen a

FGA

×

22

4

CCAAT/enhancer binding protein beta

CEBPB

×

27

3

Proteinase activated receptor 2

PAR-2

×

35

2

Plasma prekallikrein

?KLKB1

×

×

22

2

Cell chemokine 2 (MCP-1)

CCL2

×

×

11

1

Interleukin-8 receptor

IL8R

×

×

11

1

Chemokine CXC ligand 2 (MIP-2 alpha)

CXCL2

×

×

×

4

1

CC chemokine receptor 5 (CD 195)

CCR5

×

×

3

1

Annexin I

ANXA1

×

56

0

Eosinophil granule major basic protein

EBMP

×

×

56

0

Guanine nucleotide-binding protein 2

GBP2

×

38

0

Cathepsin C

CTSC

×

17

0

Interleukin-1 receptor type II

IL1R2

×

11

0

Cyclin-dependent kinase inhibitor 1 (p21)

CDKN1A

×

8

0

B-cell translocation gene 2

BTG2

×

3

0

B-cell translocation gene 1

BTG1

×

2

0

Type-2 phosphatidic acid phosphohydrolase

PAP2

×

1

0

Insulin-like growth factor binding protein 6

?IGFBP6

×

1

0

CXC chemokine receptor type 4 (LESTR)

CXCR4

×

×

×

0

0

XC chemokine ligand 1 (lymphotactin)

XCL1

×

×

0

0

Allograft inflammatory factor-1

AIF1

×

×

0

0

Linker for activation of T cells

LAT

×

0

0

B-cell antigen receptor complex protein

?CD79B

×

0

0

Abbreviation in parenthesis represents the old cytokine nomenclature. The '×' symbol designates gene ontology bioprocesses in which a given gene is involved. Numbers in PubMatrix terms columns represent citations containing the terms 'lung' and 'lung injury' terms. The '?' symbol indicates downregulated genes; all genes with unmarked gene names are upregulated. BC, blood coagulation; CT, chemotaxis; IM, immune response; IN, inflammatory response; NR, negative regulation of cell proliferation.

Grigoryev et al. Critical Care 2004 8:440   doi:10.1186/cc2901