|
Candidate genes in acute lung injury |
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| Gene Ontology |
PubMatrix terms |
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|
|
|
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| Encoded protein |
Gene symbol |
NR |
IM |
CT |
IN |
BC |
Lung |
Lung injury |
|
|
||||||||
| Interleukin-1ß |
IL1B |
× |
× |
× |
1536 |
287 |
||
| Interleukin-6 |
IL6 |
× |
963 |
173 |
||||
| Tissue factor precursor |
TF |
× |
× |
411 |
54 |
|||
| Plasminogen activator inhibitor-1 |
PAI1 |
× |
201 |
31 |
||||
| Cyclo-oxygenase-2 |
COX2 |
× |
257 |
28 |
||||
| Interleukin-13 |
IL13 |
× |
× |
327 |
21 |
|||
| Vitronectin |
?VNT |
× |
138 |
11 |
||||
| Macrophage stimulatory protein |
?MSP |
× |
102 |
11 |
||||
| Plasminogen activator, urokinase receptor |
PLAUR |
× |
× |
83 |
8 |
|||
| Tissue-type plasminogen activator |
PLAT |
× |
101 |
7 |
||||
| Fibrinogen a |
FGA |
× |
22 |
4 |
||||
| CCAAT/enhancer binding protein beta |
CEBPB |
× |
27 |
3 |
||||
| Proteinase activated receptor 2 |
PAR-2 |
× |
35 |
2 |
||||
| Plasma prekallikrein |
?KLKB1 |
× |
× |
22 |
2 |
|||
| Cell chemokine 2 (MCP-1) |
CCL2 |
× |
× |
11 |
1 |
|||
| Interleukin-8 receptor |
IL8R |
× |
× |
11 |
1 |
|||
| Chemokine CXC ligand 2 (MIP-2 alpha) |
CXCL2 |
× |
× |
× |
4 |
1 |
||
| CC chemokine receptor 5 (CD 195) |
CCR5 |
× |
× |
3 |
1 |
|||
| Annexin I |
ANXA1 |
× |
56 |
0 |
||||
| Eosinophil granule major basic protein |
EBMP |
× |
× |
56 |
0 |
|||
| Guanine nucleotide-binding protein 2 |
GBP2 |
× |
38 |
0 |
||||
| Cathepsin C |
CTSC |
× |
17 |
0 |
||||
| Interleukin-1 receptor type II |
IL1R2 |
× |
11 |
0 |
||||
| Cyclin-dependent kinase inhibitor 1 (p21) |
CDKN1A |
× |
8 |
0 |
||||
| B-cell translocation gene 2 |
BTG2 |
× |
3 |
0 |
||||
| B-cell translocation gene 1 |
BTG1 |
× |
2 |
0 |
||||
| Type-2 phosphatidic acid phosphohydrolase |
PAP2 |
× |
1 |
0 |
||||
| Insulin-like growth factor binding protein 6 |
?IGFBP6 |
× |
1 |
0 |
||||
| CXC chemokine receptor type 4 (LESTR) |
CXCR4 |
× |
× |
× |
0 |
0 |
||
| XC chemokine ligand 1 (lymphotactin) |
XCL1 |
× |
× |
0 |
0 |
|||
| Allograft inflammatory factor-1 |
AIF1 |
× |
× |
0 |
0 |
|||
| Linker for activation of T cells |
LAT |
× |
0 |
0 |
||||
| B-cell antigen receptor complex protein |
?CD79B |
× |
0 |
0 |
||||
|
Abbreviation in parenthesis represents the old cytokine nomenclature. The '×' symbol designates gene ontology bioprocesses in which a given gene is involved. Numbers in PubMatrix terms columns represent citations containing the terms 'lung' and 'lung injury' terms. The '?' symbol indicates downregulated genes; all genes with unmarked gene names are upregulated. BC, blood coagulation; CT, chemotaxis; IM, immune response; IN, inflammatory response; NR, negative regulation of cell proliferation. | ||||||||
Grigoryev et al. Critical Care 2004 8:440 doi:10.1186/cc2901 |
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