Table 1

Haemodynamics during acute lung injury in sheep
Parameter
 Group
 Time point (hours)




0
 1
 2
 3
 4
 5
 6
PVRI (dyne·s/cm5 per m2)
 Sham
 117 ± 14
 131 ± 19
 141 ± 10
 145 ± 11
 114 ± 21
 133 ± 13
 151 ± 16

LPS
 115 ± 6
 284 ± 20*†
 240 ± 21*†
 198 ± 31†
 193 ± 26*†
 199 ± 23*†
 182 ± 16*†

OA
 103 ± 9
 351 ± 64‡§
 300 ± 45‡§
 -
 -
 -
 -
GEDVI (ml/m2)
 Sham
 570 ± 46
 601 ± 68
 572 ± 43
 566 ± 12
 661 ± 74
 607 ± 67
 655 ± 60

LPS
 571 ± 23
 620 ± 57
 564 ± 32
 579 ± 42
 598 ± 38
 624 ± 42
 615 ± 37

OA
 646 ± 38
 629 ± 60
 590 ± 55
 -
 -
 -
 -
ITBVI (ml/m2)
 Sham
 764 ± 62
 806 ± 91
 766 ± 58
 759 ± 16
 886 ± 99
 813 ± 90
 878 ± 81

LPS
 765 ± 30
 831 ± 76
 756 ± 43
 776 ± 57
 801 ± 51
 836 ± 57
 825 ± 49

OA
 866 ± 51
 912 ± 42
 790 ± 74
 -
 -
 -
 -
HR (beats/min)
 Sham
 106 ± 6
 104 ± 8
 96 ± 7
 91 ± 5
 99 ± 6
 98 ± 11
 97 ± 5

LPS
 96 ± 4
 122 ± 6†
 109 ± 6
 109 ± 4*†
 109 ± 8
 122 ± 4*†
 130 ± 5*†

OA
 111 ± 5
 104 ± 13
 102 ± 13
 -
 -
 -
 -
CI (l/min per m2)
 Sham
 5.7 ± 0.3
 5.5 ± 0.3
 5.2 ± 0.3
 5.1 ± 0.2
 5.4 ± 0.4
 5.2 ± 0.3
 5.3 ± 0.3

LPS
 5.7 ± 0.1
 7.3 ± 0.5*†ll
 5.9 ± 0.2
 5.8 ± 0.3
 5.6 ± 0.4
 6.2 ± 0.3*
 6.8 ± 0.2*†

OA
 6.1 ± 0.3
 4.5 ± 0.3§
 4.6 ± 0.5
 -
 -
 -
 -
MAP (mmHg)
 Sham
 102 ± 5
 101 ± 6
 101 ± 6
 101 ± 5
 102 ± 5
 102 ± 5
 101 ± 4

LPS
 94 ± 4
 104 ± 5†
 105 ± 3†
 106 ± 4†
 105 ± 3†
 104 ± 5
 100 ± 6

OA
 94 ± 4
 101 ± 2
 104 ± 4§
 -
 -
 -
 -
SVRI (dyne·s/cm5 per m2)
 Sham
 1453 ± 101
 1496 ± 125
 1589 ± 138
 1536 ± 105
 1579 ± 109
 1607 ± 119
 1681 ± 169

LPS
 1410 ± 81
 1128 ± 102†
 1352 ± 62
 1515 ± 107
 1428 ± 101
 1308 ± 79
 1126 ± 58*†

OA
 1266 ± 63
 1847 ± 368
 1670 ± 147§
 -
 -
 -
 -

Data are expressed as mean ± standard error of the mean. *P < 0.05, LPS versus sham-operated group; †P < 0.05, versus t = 0 hours in LPS group; ‡P < 0.05, OA versus sham-operated group; §P < 0.05, versus t = 0 hours in OA group; llP < 0.05, LPS versus OA group. CI, cardiac index; GEDVI, global end-diastolic volume index; HR, heart rate; ITBVI, intrathoracic blood volume index; LPS, lipopolysaccharide; MAP, mean arterial pressure; OA, oleic acid; PVRI, pulmonary vascular resistance index; Sham, sham-operated; SVRI, systemic vascular resistance index.

Kirov et al. Critical Care 2004 8:R451   doi:10.1186/cc2974