Table 1

Comparison of cardiorespiratory variables before and after induction of lung injury


CMV (n = 8)
AV-ECMO (n = 9)


Variables
Pre-injury
Post-injury
Pre-injury
Post-injury

Minute volume (ml/kg/min)
408 ± 79
640 ± 144*
382 ± 109
561 ± 187*
PaO2 (mmHg)
389 ± 128
113 ± 85***
393 ± 131
179 ± 86***
PaCO2 (mmHg)
37.1 ± 5.1
40.9 ± 3.1
36.7 ± 1.9
35.1 ± 3
Arterial pH
7.311 ± 0.05
7.263 ± 0.04
7.349 ± 0.05
7.344 ± 0.03††
HCO3- (mmol/l)
17.7 ± 3.2
17.4 ± 1.7
19.5 ± 2.8
18.3 ± 2.1
Arterial Hb-O2 (%)
99.8 ± 0.3
89.6 ± 11
99.8 ± 0.3
95.1 ± 11
O2-extraction (%)
28.0 ± 5.7
35.9 ± 4.9*
24.7 ± 8.1
35.7 ± 9.3*
Hb (g/dl)
9.4 ± 1.5
10.3 ± 2.0
8.1 ± 2.0
8.7 ± 2.3
MAP (mmHg)
84.2 ± 12.1
88.0 ± 10.9
96.7 ± 9.0
92.0 ± 14
PAP (mmHg)
13.1 ± 4.1
20.1 ± 5.7
14.5 ± 5.4
21.5 ± 4.9*
CO (ml/kg per min)
185 ± 23
164 ± 53
181 ± 69
173 ± 56
VO2 (ml/kg per min)
5.7 ± 2.2
8.7 ± 2.7*
5.4 ± 1.5
7.8 ± 2.5*
Body weight (kg)




     All lambs
6.3 ± 1.7
-
8.5 ± 2.8
-
     Surviving lambs
-
6.5 ± 1.3
-
11.0 ± 2.2
     Range
3.6–9.2
-
5.0–12.7
-

Comparison of cardiorespiratory variables before and after induction of lung injury in surviving and nonsurviving lambs subjected to conventional mechanical ventilation (CMV) or arteriovenous (AV)-extracorporeal membrane oxygenation (ECMO) therapy. Values are expressed as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001, pre-injury baseline versus post-injury baseline in the same group. P < 0.05, ††P < 0.01, pre-injury or post-injury baselines: CMV versus AV-ECMO. CO, cardiac output; Hb-O2, hemoglobin–oxygen saturation; MAP, mean arterial pressure; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; PAP, pulmonary artery pressure; VO2, oxygen consumption.

Totapally et al. Critical Care 2004 8:R495   doi:10.1186/cc2983