|
Hemodynamics and oxygen consumption |
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| Study period (hours after establishment of acute lung injury) |
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|
|
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| Variables |
0 (baseline) |
2 |
4 |
6 |
|
|
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| Minute ventilation (ml/kg per min) |
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| CMV |
624 ± 189 |
550 ± 152 |
590 ± 151 |
608 ± 192 |
| AV-ECMO |
397 ± 96 |
214 ± 83†* |
222 ± 128†* |
256 ± 155†* |
| MAP (mmHg) |
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| CMV |
89.6 ± 12.2 |
81.5 ± 10.1 |
83.8 ± 17.0 |
82.5 ± 9.0 |
| AV-ECMO |
92.5 ± 10.6 |
90.0 ± 16.2 |
73.5 ± 25.0 |
74.5 ± 40 |
| PAP (mmHg) |
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| CMV |
20.8 ± 6.4 |
23.1 ± 7.7 |
22.6 ± 3.7 |
18.6 ± 6.8 |
| AV-ECMO |
19.0 ± 5.7 |
24.7 ± 7.5* |
26.2 ± 7.8* |
26.2 ± 9.3* |
| Cardiac output (ml/kg per min) |
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| CMV |
164 ± 45 |
165 ± 28 |
189 ± 62 |
194 ± 54 |
| AV-ECMO |
144 ± 56 |
177 ± 30 |
143 ± 47 |
184 ± 54 |
| Oxygen consumption (ml/kg per min) |
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| CMV |
9.6 ± 2.4 |
9.2 ± 1.5 |
10.1 ± 3.4 |
8.9 ± 3.7 |
| AV-ECMO |
7.1 ± 1.7 |
9.7 ± 2.3 |
8.1 ± 1.3 |
8.2 ± 3.7 |
|
Hemodynamics and oxygen consumption in lung injured lambs (surviving) supported by conventional mechanical ventilation (CMV; n = 6) or arteriovenous (AV)-extracorporeal membrane oxygenation (ECMO; n = 4) during a 6-hour period of study. Values are expressed as mean ± standard deviation. *P < 0.05, baseline (time 0) versus 2, 4, and 6 hours of study by repeated measures analysis of variance (ANOVA) followed by Dunnett multiple comparisons test. †P < 0.05, CMV versus AV-ECMO groups; ANOVA followed by Bonferoni multiple comparisons test. | ||||
Totapally et al. Critical Care 2004 8:R495 doi:10.1186/cc2983 |
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