|
Gas exchage variables |
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| Study period (hours after establishment of acute lung injury) |
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|
|
||||
| Variable |
0 (baseline) |
2 |
4 |
6 |
|
|
||||
| PaO2 (mmHg) |
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| CMV |
131 ± 90 |
207 ± 171 |
231 ± 175 |
221 ± 189 |
| AV-ECMO |
174 ± 100 |
95 ± 29 |
77 ± 17* |
94 ± 76 |
| PaCO2 (mmHg) |
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| CMV |
41.3 ± 3.1 |
43.4 ± 8.3 |
38.9 ± 10.3 |
37.0 ± 7.1 |
| AV-ECMO |
34.8 ± 2.3** |
35.1 ± 8.5 |
37.1 ± 7.8 |
37.8 ± 5.7 |
| pH |
||||
| CMV |
7.263 ± 0.05 |
7.237 ± 0.05 |
7.286 ± 0.10 |
7.289 ± 0.08 |
| AV-ECMO |
7.322 ± 0.04* |
7.277 ± 0.15 |
7.235 ± 0.10 |
7.207 ± 0.14 |
| HCO3- (mmol/l) |
||||
| CMV |
17.0 ± 3.1 |
16.8 ± 3.2 |
16.7 ± 2.7 |
15.9 ± 3.3 |
| AV-ECMO |
17.2 ± 2.4 |
15.7 ± 2.3 |
15.7 ± 5.4 |
14.6 ± 4.6 |
| Arterial Hb-O2 (%) |
||||
| CMV |
91.8 ± 8.1 |
89.2 ± 14.9 |
94.0 ± 4.9 |
88.9 ± 18.4 |
| AV-ECMO |
90.7 ± 16.5 |
89.0 ± 9.9 |
84.4 ± 7.0 |
74.0 ± 24.8 |
| O2 extraction (%) |
||||
| CMV |
42.4 ± 15.6 |
37.6 ± 9.2 |
47.2 ± 11.5 |
41.2 ± 6.9 |
| AV-ECMO |
41.6 ± 11.9 |
37.3 ± 14.2 |
49.3 ± 21.0 |
43.3 ± 21.7 |
|
Gas exchage variables in lung injured lambs (surviving) supported by conventional mechanical ventilation (CMV; n = 6) or arteriovenous (AV)-extracorporeal membrane oxygenation (ECMO; n = 4) during a 6-hour period of study. No significant differences were found when comparing baselines (time 0) with 2, 4, and 6 hours of study by repeated measures analysis of variance (ANOVA) followed by Dunnett multiple comparisons test. Values are expressed as mean ± standard deviation. *P < 0.05, **P < 0.01, CMV versus AV-ECMO group; ANOVA followed by Bonferroni multiple comparisons test. Hb-O2, hemoglobin–oxygen saturation; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension. | ||||
Totapally et al. Critical Care 2004 8:R495 doi:10.1186/cc2983 |
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