|
Red blood cell storage lesion |
|
| Storage effects |
Consequences |
|
|
|
| Decreased 2, 3-diphosphoglycerate |
Increased oxygen affinity and decreased oxygen unloading by hemoglobin |
|
|
|
| ATP depletion |
Erythrocyte shape changes |
| Increased osmotic fragility |
|
| Decreased deformability |
|
|
|
|
| Microvesiculation and loss of lipid membrane |
Decreased erythrocyte viability |
|
|
|
| Lipid peroxidation |
Cellular injury and death |
|
|
|
| Bioactive substance generation: histamine, cytokines, lipids |
Febrile transfusion reactions |
| Neutrophil priming/endothelial activation |
|
| Cellular injury |
|
| Transfusion-related acute lung injury |
|
| Multiple organ failure (?) |
|
|
|
|
Offner Critical Care 2004 8(Suppl 2):S24 doi:10.1186/cc2405 |
|