Table 2

Summary of studies of dantrolene treatment of heat stroke in animals
Reference
 Study type
 Model
 Numbers included
 Dantrolene dose (mg/kg bw)
 Improved parameters
 Nonimproved parameters
[18]
 Randomized controlled
 Exercising rats
 7
 140
 Cooling rate
 -


Nonexercising rats
 7
 140
 -
 Cooling rate
[19]
 Randomized controlled
 Nonexercising piglets
 4
 3
 Cooling ratea
 Cardivascular parameters
[16]
 Randomized controlled
 Nonexercising dogs
 5
 5
 -
 Cooling rate, haemodynamic parameters, pathological changes, clinical outcome

aImprovement was reported with or without mannitol. bw, Body weight

Hadad et al. Critical Care 2005 9:86   doi:10.1186/cc2923