Table 3

Summary of studies of dantrolene pretreatment of heat stroke in animals



Numbers included








Reference
 Study type
 Model
 Dantrolene treatment arms
 Control arms
 Dantrolene dose (mg/kg bw)
 Improved parameters
 Nonimproved parameters
[20]
 Randomized controlled
 Exercising sheep
 6
 6
 1.5–3
 Body temperature, Severity of heat stroke signs, changes in serum enzymes and hormones, survivala
 -
[18]
 Randomized controlled
 Exercising rats
 7
 7
 140
 -
 Physical capacity


Nonexercising rats
 7
 7
 140
 Endurance in the heat
 -

aTrend only. bw, Body weight.

Hadad et al. Critical Care 2005 9:86   doi:10.1186/cc2923