|
Assessment of blood–brain barrier permeability by Evans blue dye content in brain tissue |
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| Measurement |
Group (n) |
Left hemisphere |
Right hemisphere |
P |
|
|
||||
| EB dye (μg/g) |
C (8) |
0.00160 ± 0.0003 |
0.00145 ± 0.0003 |
0.33 |
| S (8) |
0.00466 ± 0.0002a,b |
0.00641 ± 0.0003c,d |
0.13 |
|
| C-Mg (8) |
0.00135 ± 0.0002 |
0.00145 ± 0.0003 |
0.44 |
|
| S-Mg (8) |
0.00218 ± 0.0005 |
0.00199 ± 0.0007 |
0.57 |
|
| KW |
19.720 |
23.039 |
||
| d.f. |
3 |
3 |
||
| P |
< 0.001 |
< 0.0001 |
||
|
Abbreviations: d.f., degrees of freedom; EB, Evans blue; KW, Kruskal–Wallis test statistic; P, approximate χ2 P value. Groups: sham control (C), sham control MgSO4-treated (C-Mg), septic (S) and septic MgSO4-treated (S-Mg). Data are expressed as means ± standard deviation. Dunn's multiple comparisons test: aseptic versus sham control, P < 0.01; bseptic versus sham control MgSO4-treated, P < 0.001; cseptic versus sham control, P < 0.001; dseptic versus sham control MgSO4-treated, P < 0.001. A Mann–Whitney test was used for within-group comparisons. Two-tailed P values are shown in the last column. | ||||
Esen et al. Critical Care 2005 9:R18 doi:10.1186/cc3004 |
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