Changes in haemodynamic parameters. Administration of endotoxin (2 ng/kg; n = 8; closed squares) resulted in a significant increase in heart rate (HR; measured using electrocardiography; P < 0.0001), a significant decrease in mean arterial pressure (MAP; measured intra-arterially; P < 0.0001) and a significant increase in forearm blood flow (FBF; measured using venous occlusion plethysmography; P = 0.018). HR and FBF did not change significantly in the control group (open circles; n = 8), whereas MAP decreased (P = 0.035). MAP decreased significantly more in the endotoxin group than in the control group (P = 0.002). These changes demonstrate that endotoxin induces a vasodilatory state. Data are expressed as means ± standard error of the mean. The P values in the figure refer to the difference between endotoxin and control group as analyzed using analysis of variance with repeated measures over the complete curve.
van Eijk et al. Critical Care 2005 9:R157 doi:10.1186/cc3050