Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised trial [ISRCTN47583497]

Des Breen¹ , Andreas Karabinis² , Manu Malbrain³ , Rex Morais⁴ , Sven Albrecht⁵ , Inge-Lise Jarnvig⁶ , Pauline Parkinson⁷ and Andrew JT Kirkham⁸

¹Consultant in Anaesthesia and Intensive Care, Royal Hallamshire Hospital, Sheffield, UK

²Director of Intensive Care Unit, Genimatas General Hospital, Athens, Greece

³Director of Intensive Care Unit, ZiekenhuisNetwerk Antwerpen, Antwerpen, Belgium

⁴Consultant Anaesthetist, Intensive Care Unit, Dubai Hospital, Dubai, United Arab Emirates

⁵Deputy Director, Universität Erlangen-Nürnberg, Klinik für Anästhesiologie, Erlangen, Germany

⁶Senior Registrar, Intensive Care Unit, Righospitalet, Copenhagan, Denmark

⁷Clinical Scientist, Neurosciences Medicines Development Centre, GlaxoSmithKline, Greenford, Middlesex, UK

⁸Clinical Development Director, Neurosciences Medicines Development Centre, GlaxoSmithKline, Greenford, Middlesex, UK