Renal blood flow in sepsis: a complex issue

doi:10.1186/cc3740

Critical Care
Volume 9
Issue 4

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Commentary

Renal blood flow in sepsis: a complex issue

Bruce A Molitoris

Division of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA, and The Roudebush VA Medical Center, Indianapolis, IN, USA

author email corresponding author email

Critical Care 2005, 9:327-328doi:10.1186/cc3740


Published:	2 June 2005

See related research article http://ccforum.com/content/9/4/R363

Abstract

The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.