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Baseline characteristics of adult severe sepsis patients with purpura fulminans, meningitis, or meningococcal disease |
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| Baseline characteristics1 |
No PF, MEN, or MD n = 3,907 (816 PLC) |
PF, MEN, or MD n = 189 (24 PLC) |
PF n = 77 (5 PLC) |
MEN n = 128 (21 PLC) |
MD n = 92 (10 PLC) |
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| Demographics and disease severity |
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| Age (years), mean ± SD |
60.3 ± 16.5 |
44.4 ± 19.6 |
34.6 ± 14.4 |
48.2 ± 20.4 |
34.9 ± 16.1 |
| Male (%) |
57.8 |
53.4 |
58.4 |
53.1 |
50.0 |
| Caucasian (%) |
86.8 |
91.0 |
92.2 |
91.4 |
89.1 |
| Organ dysfunctions, median; q1-q3 |
3.0; 2.0–3.0 |
2.0; 1.0–4.0 |
3.0; 2.0–4.0 |
2.0; 1.0–3.0 |
2.0; 2.0–4.0 |
| First organ dysfunction to infusion (h), mean ± SD |
22.6 ± 13.0 |
18.3 ± 13.2 |
13.5 ± 11.8 |
18.5 ± 13.4 |
14.9 ± 11.3 |
| APACHE II score, mean ± SD |
23.2 ± 7.6 |
22.6 ± 8.1 |
22.3 ± 7.8 |
22.0 ± 7.9 |
21.9 ± 7.8 |
| GCS score, mean ± SD |
12.2 ± 3.8 |
10.3 ± 4.1 |
11.8 ± 3.8 |
9.8 ± 4.0 |
11.2 ± 4.1 |
| Underlying comorbidities |
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| Congestive cardiomyopathy (%) |
5.7 |
0 |
0 |
0 |
0 |
| COPD (%) |
19.4 |
3.1 |
0 |
4.0 |
1.3 |
| Diabetes (%) |
21.0 |
9.9 |
2.0 |
11.3 |
5.1 |
| Hypertension (%) |
36.7 |
18.0 |
6.1 |
20.2 |
7.7 |
| Liver disease (%) |
2.9 |
2.5 |
4.1 |
2.4 |
2.6 |
| Cancer (%) |
16.3 |
7.5 |
2.0 |
8.1 |
5.1 |
| Myocardial infarction (%) |
11.6 |
1.9 |
0 |
2.4 |
0 |
| Pancreatitis (%) |
3.7 |
1.2 |
0 |
1.6 |
1.3 |
| Recent trauma (%) |
3.9 |
1.9 |
4.1 |
1.6 |
1.3 |
| Recent surgery (%) |
35.5 |
1.9 |
4.1 |
1.6 |
1.3 |
| Coagulation biomarkers |
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| Protein C level (%), median; q1-q3 |
46; 30–64 |
47; 30–67 |
30; 20–45 |
54; 38–74 |
40; 27–53 |
| Platelet count, median; q1-q3 |
172; 105–249 |
91; 45–142 |
59; 35–95 |
119; 65–159 |
70; 34–121 |
| APTT (s), median; q1-q3 |
41; 34–50 |
44; 35–55 |
48; 41–63 |
40; 34–49 |
48; 38–62 |
| PT (s), median; q1-q3 |
18; 15–21 |
17; 15–22 |
17; 14–23 |
17; 15–21 |
19; 16–23 |
| Cardiovascular and respiratory measures |
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| Vasopressor (%) |
69.6 |
60.1 |
76.6 |
47.2 |
72.5 |
| Ventilator (%) |
79.3 |
79.8 |
80.5 |
76.4 |
76.9 |
| Cardiovascular study entry criteria (%) |
78.8 |
68.3 |
77.6 |
64.5 |
79.5 |
| Respiratory study entry criteria (%) |
80.5 |
57.8 |
59.2 |
54.0 |
47.4 |
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1Patients with missing data were excluded from this analysis. APACHE II, Acute Physiology and Chronic Health Evaluation II; APTT, activated partial thromboplastin time; COPD, chronic obstructive pulmonary disease; GCS, Glasgow Coma Scale; MD, meningococcal disease; MEN, meningitis; PF, purpura fulminans; PLC, placebo; PT, prothrombin time. | |||||
Vincent et al. Critical Care 2005 9:R331 doi:10.1186/cc3538 |
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