Critical Care
Volume 9
Issue 5 |
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This article is part of a series on Sepsis, edited by Bruno Levy.ReviewClinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsisSébastien Gibot  Service de Réanimation Médicale, 29 Avenue du Maréchal de Lattre de Tassigny, Hôpital Central, Nancy, France  author email corresponding author email
Critical Care 2005,
9:485-489doi:10.1186/cc3732 Abstract
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule that is involved in monocytic activation and in the inflammatory response. It belongs to a family related to the natural killer cell receptors and is expressed on neutrophils, mature monocytes and macrophages. The inflammatory response mediated by Toll-like receptor-2 and -4 stimulation is amplified by the engagement of TREM-1. The expression of membrane-bound TREM-1 is greatly increased on monocytes during sepsis. Moreover, infection induces the release of a soluble form of this receptor, which can be measured in biological fluid and may be useful as a diagnostic tool. Modulation of the TREM-1 signalling pathway by the use of small synthetic peptides confers interesting survival advantages during experimental septic shock in mice, even when this teatment is administered late after the onset of sepsis. | 
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