Figure 3.

Overview of the role of TREM-1 in sepsis. DAG, diacylglycerol; ERK, extracellular signal regulated kinase; GRB, growth factor receptor binding protein; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated protein kinase kinase; PAMP, pathogen-associated molecular pattern; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; PLC, phospholipase C; SOS, son of sevenless; TLR, Toll-like receptor; TREM, triggering receptor expressed on myeloid cells; TREM-1L, TREM-1 ligand.