Figure 3.

Distribution of reported APACHE II scores in the PROGRESS registry. The darker shading (outer envelope) of these plots represents the observed distribution of APACHE II scores of 5,253 severe sepsis patients in the PROGRESS registry. The lighter shading (inner envelope) is calculated by applying the probability of misclassification for each individual APACHE II score based on assumed standard deviation (SD) of (from top to bottom) 6, 9 and 12 and on an APACHE II cut-off score ≥25.