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Therapeutic interventions and changes in physiological parameters during the 8-hour study period |
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| Parameter |
Control group |
GDT group |
p |
|
|
|||
| Intervention |
|||
| Crystalloid (ml) |
960 ± 335 |
930 ± 221 |
0.39 |
| Colloid (ml) |
1,204 ± 898 |
1,907 ± 878 |
<0.0001 |
| Blood (ml) |
0 (0–485) |
125 (0–734) |
0.10 |
| Dopexamine (μg kg-1 min-1) |
0.0 (0.0–0.0) |
0.75 (0.5–1.0) |
<0.0001 |
| Change in variable |
|||
| DO2I (ml min-1 m-2) |
-10 ± 190 |
+163 ± 249 |
0.0001 |
| Stroke volume (ml) |
-7.2 ± 28.7 |
+6.7 ± 26.1 |
0.01 |
| CVP (mmHg) |
-1.6 ± 6.8 |
-2.1 ± 5.4 |
0.69 |
| Serum lactate (mmol l-1) |
-0.6 ± 1.1 |
-0.3 ± 0.8 |
0.11 |
|
Data are presented as mean ± SD or median (interquartile range). CVP, central venous pressure; DO2I, oxygen delivery index. GDT, goal-directed therapy. | |||
Pearse et al. Critical Care 2005 9:R687 doi:10.1186/cc3887 |
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