Table 1

TNF-α and IL-6 in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody

Time (hours)

-0.5
 0
 1
 2
 4
 6
 10
 24
 32
 48
 72
TNF-α (pg/ml)










     Placebo
 0 ± 0
 2 ± 2
 5,950 ± 1,762
 6,325 ± 2,026
 244 ± 71
 55 ± 18
 28 ± 15
 21 ± 7
 19 ± 7
 8 ± 5
 0 ± 0
     L-SEL-Ab
 6 ± 4
 1 ± 1
 9,048 ± 2,227
 6,648 ± 1,465
 236 ± 45
 60 ± 9
 39 ± 7
 33 ± 11
 34 ± 11
 37 ± 15
 39 ± 15
IL-6 (pg/ml)










     Placebo
 4 ± 3
 17 ± 8
 2,059 ± 263
 6,968 ± 718
 7,331 ± 963
 6,082 ± 832
 5,364 ± 773
 3,032 ± 900
 1,921 ± 860
 2,435 ± 1,635
 896 ± 73
     L-SEL-Ab
 13 ± 5
 6 ± 4
 2,270 ± 665
 7,392 ± 802
 7,490 ± 773
 7,075 ± 765
 5,952 ± 500
 3,547 ± 644
 2,550 ± 689
 1,684 ± 761
 907 ± 77

IL-6, interleukin-6; L-SEL-Ab, anti-L-selectin antibody; TNF-α, tumor necrosis factor-α.

Redl et al. Critical Care 2005 9:R735   doi:10.1186/cc3825