Table 2

Hemodynamic responses in baboons infused with live Escherichia coli and treated with placebo or anti-L-selectin antibody

Time (hours)

-0.5
 0
 1
 2
 4
 6
 10
 24
 32
 48
 72
Heart rate (beats/minute)










     Placebo
 124 ± 3
 125 ± 3
 156 ± 9
 171 ± 7
 170 ± 5
 160 ± 5
 141 ± 7
 142 ± 6
 138 ± 9
 139 ± 5
 151 ± 11
     L-SEL-Ab
 122 ± 5
 121 ± 4
 160 ± 9
 177 ± 7
 165 ± 3
 168 ± 6
 151 ± 5
 142 ± 15
 141 ± 14
 143 ± 10
 158 ± 10
MAP (mmHg)










     Placebo
 113 ± 6
 122 ± 3
 102 ± 8
 72 ± 5
 103 ± 5
 117 ± 6
 95 ± 9
 75 ± 11
 75 ± 6
 65 ± 11
 70 ± 6
     L-SEL-Ab
 119 ± 4
 122 ± 3
 104 ± 6
 72 ± 5
 97 ± 5
 111 ± 6
 85 ± 10
 51 ± 8
 51 ± 7
 61 ± 12
 79 ± 8
CO (l/minute)










     Placebo
 3.1 ± 0.2
 3.2 ± 0.2
 4.3 ± 0.4
 4.6 ± 0.4
 4.4 ± 0.4
 4.2 ± 0.4
 2.5 ± 0.2
 3.5 ± 0.4
 4.2 ± 0.3
 3.6 ± 0.3
 3.7 ± 0.2
     L-SEL-Ab
 3.1 ± 3.1
 3.1 ± 3.1
 4.8 ± 4.8
 5.5 ± 5.5
 4.8 ± 4.8
 4.6 ± 4.6
 2.5 ± 2.5
 3.0 ± 3.0
 3.8 ± 3.8
 3.6 ± 3.6
 3.8 ± 3.8
MPAP (mmHg)










     Placebo
 13 ± 1
 14 ± 1
 14 ± 1
 13 ± 1
 14 ± 2
 18 ± 2
 17 ± 3
 17 ± 2
 18 ± 3
 15 ± 1
 16 ± 3
     L-SEL-Ab
 13 ± 1
 13 ± 1
 13 ± 1
 14 ± 1
 14 ± 1
 18 ± 1
 16 ± 1
 16 ± 2
 16 ± 1
 16 ± 1
 15 ± 3
PWP (mmHg)










     Placebo
 3.5 ± 0.4
 3.6 ± 0.5
 4.4 ± 0.8
 4.5 ± 1.0
 4.8 ± 0.9
 5.4 ± 0.8
 1.4 ± 0.6
 1.5 ± 0.5
 3.5 ± 0.3
 2.0 ± 0.7
 1.5 ± 1.0
     L-SEL-Ab
 4.6 ± 0.7
 4.5 ± 0.6
 4.8 ± 0.6
 5.5 ± 0.9
 4.6 ± 0.8
 4.9 ± 0.8
 2.9 ± 0.6
 2.8 ± 0.4
 2.7 ± 0.4
 3.6 ± 0.9
 3.7 ± 0.3
PVR (dyn s cm-5)










     Placebo
 264 ± 21
 258 ± 16
 180 ± 11
 160 ± 17
 180 ± 20
 265 ± 41
 542 ± 112
 399 ± 80
 285 ± 58
 292 ± 22
 301 ± 78
     L-SEL-Ab
 220 ± 20
 223 ± 18
 142 ± 22
 124 ± 15
 162 ± 21
 243 ± 30
 441 ± 58
 362 ± 50
 296 ± 27
 267 ± 25
 279 ± 70
arterial pO2 (mmHg)










     Placebo
 100.4 ± 6.8
 101.5 ± 6.9
 97.7 ± 5.2
 104.8 ± 4.5
 105.0 ± 4.3
 100.2 ± 4.3
 88.2 ± 2.5
 84.7 ± 4.6
 76.7 ± 6.4
 73.1 ± 7.0
 63.4 ± 6.5
     L-SEL-Ab
 101.9 ± 5.9
 102.2 ± 4.4
 105.0 ± 6.3
 109.9 ± 4.0
 105.9 ± 5.7
 103.6 ± 6.0
 91.0 ± 5.7
 89.1 ± 5.4
 82.2 ± 3.5
 88.7 ± 7.5
 77.6 ± 8.3
arterial pCO2 (mmHg)










     Placebo
 48.8 ± 1.1
 46.4 ± 1.0
 45.0 ± 1.2
 41.1 ± 1.2
 34.6 ± 2.3
 36.3 ± 0.9
 33.2 ± 1.1
 33.9 ± 1.9
 34.1 ± 2.4
 40.5 ± 3.2
 45.7 ± 3.3
     L-SEL-Ab
 43.7 ± 1.5
 43.1 ± 1.5
 40.9 ± 0.4
 39.1 ± 0.9
 35.0 ± 1.7
 34.5 ± 0.9
 28.9 ± 2.3
 31.5 ± 2.3
 33.0 ± 3.4
 35.3 ± 4.3
 40.7 ± 6.1

arterial pCO2, arterial partial carbondioxide pressure; arterial pO2, arterial partial oxygen pressure; CO, cardiac output; L-SEL-Ab, anti-L-selectin antibody; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; PWP, pulmonary arterial wedge pressure; PVR, peripheral vascular resistance.

Redl et al. Critical Care 2005 9:R735   doi:10.1186/cc3825