Table 4

Fluid infusion requirements

Time (hours)

-0.5
 0
 1
 2
 4
 6
 10
 24
 32
 48
 72
Ringer (ml/kg BW)










     Placebo
 1 ± 0
 7 ± 0
 21 ± 2
 40 ± 4
 92 ± 4
 134 ± 6
 135 ± 6
 159 ± 7
 186 ± 11
 223 ± 13
 250 ± 19
     L-SEL-Ab
 1 ± 0
 7 ± 0
 20 ± 2
 38 ± 4
 90 ± 6
 130 ± 9
 131 ± 10
 157 ± 11
 189 ± 16
 204 ± 9
 219 ± 16
Hematocrit (%)










     Placebo
 42.1 ± 1.3
 40.3 ± 1.1
 37.8 ± 1.2
 35.7 ± 1.4
 36.4 ± 1.6
 36.6 ± 1.4
 40.8 ± 1.5
 35.4 ± 2.3
 29.1 ± 2.0
 27.5 ± 1.6
 26.0 ± 2.5
     L-SEL-Ab
 40.7 ± 1.6
 38.6 ± 1.7
 37.8 ± 1.5
 34.8 ± 1.3
 35.5 ± 1.4
 36.5 ± 1.5
 40.4 ± 1.8
 34.3 ± 1.5
 31.4 ± 1.6
 29.7 ± 1.2
 28.6 ± 2.2
Protein (g/100 ml)










     Placebo
 6.5 ± 0.2
 6.1 ± 0.1
 5.3 ± 0.2
 4.5 ± 0.2
 4.2 ± 0.1
 4.1 ± 0.1
 4.8 ± 0.1
 4.6 ± 0.1
 4.4 ± 0.2
 4.1 ± 0.3
 4.5 ± 0.4
     L-SEL-Ab
 6.0 ± 0.2
 5.7 ± 0.2
 5.0 ± 0.1
 4.1 ± 0.1
 4.0 ± 0.1
 4.0 ± 0.2
 4.5 ± 0.2
 4.1 ± 0.2
 4.0 ± 0.2
 4.0 ± 0.3
 4.4 ± 0.4

Accumulation amount of Ringer's solution over time, hematocrit and total plasma protein concentration in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody (L-SEL-Ab). BW = body weight.

Redl et al. Critical Care 2005 9:R735   doi:10.1186/cc3825