Table 5 |
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|
Kidney and liver function |
|||||||||||
|
Time (hours) |
|||||||||||
|
|
|||||||||||
|
-0.5 |
0 |
1 |
2 |
4 |
6 |
10 |
24 |
32 |
48 |
72 |
|
|
|
|||||||||||
|
Creatinine (μmol/l) |
|||||||||||
|
Placebo |
86 ± 3 |
81 ± 5 |
78 ± 6 |
80 ± 6 |
93 ± 6 |
97 ± 11 |
133 ± 18 |
200 ± 48 |
189 ± 73 |
112 ± 10 |
96 ± 7 |
|
L-SEL-Ab |
105 ± 6 |
96 ± 7 |
88 ± 7 |
93 ± 5 |
104 ± 6 |
109 ± 7 |
145 ± 16 |
240 ± 42 |
276 ± 65 |
226 ± 90a |
121 ± 12 |
|
Urine output (ml/h) |
|||||||||||
|
Placebo |
nd |
43.8 ± 11.0 |
31.9 ± 9.3 |
63.75 ± 29.0 |
111.3 ± 95.8 |
124.4 ± 34.3 |
84.4 ± 17.5 |
87.1 ± 27.2 |
80.8 ± 25.0 |
69.0 ± 12.6 |
nd |
|
L-SEL-Ab |
nd |
36.88 ± 11.1 |
38.1 ± 12.3 |
66.9 ± 26.4 |
161.9 ± 42.0 |
122.5 ± 41.1 |
94.4 ± 25.6 |
79.4 ± 16.4 |
55.0 ± 7.2 |
72.0 ± 7.3 |
nd |
|
BUN (mg/dl) |
|||||||||||
|
Placebo |
12.7 ± 1.2 |
12.1 ± 1.3 |
13.2 ± 1.3 |
12.2 ± 1.4 |
11.7 ± 1.4 |
11.9 ± 1.2 |
17.9 ± 2.0 |
30.8 ± 1.8 |
34.1 ± 4.3 |
38.0 ± 7.3 |
30.5 ± 4.3 |
|
L-SEL-Ab |
13.7 ± 2.2 |
13.6 ± 2.2 |
11.6 ± 1.8 |
12.8 ± 2.1 |
11.9 ± 2.2 |
12.4 ± 2.0 |
16.4 ± 2.0 |
32.7 ± 2.5 |
39.7 ± 3.4 |
41.9 ± 6.3 |
31.6 ± 4.1 |
|
ALT (U/l) |
|||||||||||
|
Placebo |
12 ± 3 |
12 ± 2 |
9 ± 2 |
8 ± 2 |
25 ± 11 |
46 ± 20 |
78 ± 27 |
112 ± 21 |
93 ± 24 |
68 ± 12 |
71 ± 18 |
|
L-SEL-Ab |
13 ± 2 |
10 ± 2 |
7 ± 0 |
7 ± 2 |
13 ± 4 |
16 ± 5 |
37 ± 13 |
93 ± 35 |
110 ± 28 |
100 ± 26 |
100 ± 30 |
|
|
|||||||||||
|
Organ function in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody. ap = 0.047. ALT, alanine transferase; BUN, blood urea nitrogen; L-SEL-Ab, anti-L-selectin antibody; nd, not done. |
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|
Redl et al. Critical Care 2005 9:R735 doi:10.1186/cc3825 |
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