Table 5

Kidney and liver function

Time (hours)

-0.5
 0
 1
 2
 4
 6
 10
 24
 32
 48
 72
Creatinine (μmol/l)










     Placebo
 86 ± 3
 81 ± 5
 78 ± 6
 80 ± 6
 93 ± 6
 97 ± 11
 133 ± 18
 200 ± 48
 189 ± 73
 112 ± 10
 96 ± 7
     L-SEL-Ab
 105 ± 6
 96 ± 7
 88 ± 7
 93 ± 5
 104 ± 6
 109 ± 7
 145 ± 16
 240 ± 42
 276 ± 65
 226 ± 90a
 121 ± 12
Urine output (ml/h)










     Placebo
 nd
 43.8 ± 11.0
 31.9 ± 9.3
 63.75 ± 29.0
 111.3 ± 95.8
 124.4 ± 34.3
 84.4 ± 17.5
 87.1 ± 27.2
 80.8 ± 25.0
 69.0 ± 12.6
 nd
     L-SEL-Ab
 nd
 36.88 ± 11.1
 38.1 ± 12.3
 66.9 ± 26.4
 161.9 ± 42.0
 122.5 ± 41.1
 94.4 ± 25.6
 79.4 ± 16.4
 55.0 ± 7.2
 72.0 ± 7.3
 nd
BUN (mg/dl)










     Placebo
 12.7 ± 1.2
 12.1 ± 1.3
 13.2 ± 1.3
 12.2 ± 1.4
 11.7 ± 1.4
 11.9 ± 1.2
 17.9 ± 2.0
 30.8 ± 1.8
 34.1 ± 4.3
 38.0 ± 7.3
 30.5 ± 4.3
     L-SEL-Ab
 13.7 ± 2.2
 13.6 ± 2.2
 11.6 ± 1.8
 12.8 ± 2.1
 11.9 ± 2.2
 12.4 ± 2.0
 16.4 ± 2.0
 32.7 ± 2.5
 39.7 ± 3.4
 41.9 ± 6.3
 31.6 ± 4.1
ALT (U/l)










     Placebo
 12 ± 3
 12 ± 2
 9 ± 2
 8 ± 2
 25 ± 11
 46 ± 20
 78 ± 27
 112 ± 21
 93 ± 24
 68 ± 12
 71 ± 18
     L-SEL-Ab
 13 ± 2
 10 ± 2
 7 ± 0
 7 ± 2
 13 ± 4
 16 ± 5
 37 ± 13
 93 ± 35
 110 ± 28
 100 ± 26
 100 ± 30

Organ function in baboons infused with live Escherichia coli and treated with either placebo or anti-L-selectin antibody. ap = 0.047.

ALT, alanine transferase; BUN, blood urea nitrogen; L-SEL-Ab, anti-L-selectin antibody; nd, not done.

Redl et al. Critical Care 2005 9:R735   doi:10.1186/cc3825