Table 1 |
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|
Differential regulation of endotoxic microcirculatory disorders by coagulatory inhibitors |
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|
Action on microcirculation |
LPS |
APC |
AT |
Hirudin |
|
|
||||
|
Leukocyte rolling 8/24 hours |
↑ |
↓ |
↑ |
↑ |
|
Arteriolar leukocyte adhesion |
↑ |
↓ |
↓ |
↑ |
|
Venular leukocyte adhesion |
↑ |
↓ |
↓ |
↑ |
|
Capillary perfusion |
↓ |
= |
= |
↓ |
|
|
||||
|
Note that hirudin is not antiadhesive and does not protect against endotoxic capillary dysfunction. LPS, lipopolysaccharide; APC, activated protein C; AT, antithrombin. |
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|
Hoffmann et al. Critical Care 2005 9(Suppl 4):S33 doi:10.1186/cc3758 |
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