Critical Care

official impact factor 4.60

This article is part of the supplement: Re-establishing organ function in severe sepsis: targeting the microcirculation

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New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated)

William L Macias, S Betty Yan, Mark D Williams, Suzane L Um, George E Sandusky, Darryl W Ballard and Jean-Michel S Planquois*

Critical Care 2005, 9(Suppl 4):S38-S45 doi:10.1186/cc3747

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Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort

Richard V Hodder, Richard Hall, James A Russell, Harold N Fisher, Bobbie Lee Critical Care 2009, 13:R78 (20 May 2009)

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The protein C pathway: implications for the design of the RESPOND study

Burkhard Vangerow, Andrew F Shorr, Duncan Wyncoll, Jonathan Janes, David R Nelson, Konrad Reinhart Critical Care 2007, 11(Suppl 5):S4 (19 December 2007)

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Diagnosis and treatment of severe sepsis

Yann-Erick Claessens, Jean-François Dhainaut Critical Care 2007, 11(Suppl 5):S2 (19 December 2007)

Case report   Open Access

Severe sepsis due to severe falciparum malaria and leptospirosis co-infection treated with activated protein C

Rajagopala Srinivas, Ritesh Agarwal, Dheeraj Gupta Malaria Journal 2007, 6:42 (12 April 2007)

Dual infections are common and under-recognized in the tropics. Failure to treat potential co-infections may lead to poor outcomes.

Research   Open Access

Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat

Christian Lehmann, Konrad Meissner, Andreas Knöck, Stephan Diedrich, Dragan Pavlovic, Matthias Gründling, Taras Usichenko, Michael Wendt, Jürgen Birnbaum Critical Care 2006, 10:R157 (13 November 2006)