|
Concentrations of protein C, APC, or rhAPC in humans |
|
| Concentrations (ng/ml) |
|
|
|
|
| Normal endogenous protein C levels |
4,000 |
| Normal endogenous APC levels |
1 |
| rhAPC in PROWESS patients (median steady-state levels) |
45 |
| Levels of APC/rhAPC used in many non-clinical in vitro/in vivo studies |
1,000–20,000 |
|
APC, activated protein C; PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; rhAPC, recombinant human activated protein C (drotrecogin alfa [activated]). | |
Macias et al. Critical Care 2005 9(Suppl 4):S38 doi:10.1186/cc3747 |
|