Table 2 |
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|
Concentrations of thrombin used in experiments |
|
|
Concentration (nM) |
|
|
|
|
|
Most historical experiments |
20–500 |
|
EC50 for PAR-1 activation |
0.05 |
|
Baseline levels of markers of thrombin generation in PROWESS patients (severe sepsis) |
~0.1–1 |
|
More recent studies of APC's effects on thrombin/PAR-1/endothelial cells |
0.02–1 |
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|
|
|
APC, activated protein C; EC50, Concentration inducing half-maximum activation of PAR-1; PAR-1, protease-activated receptor 1; PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis. |
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Macias et al. Critical Care 2005 9(Suppl 4):S38 doi:10.1186/cc3747 |
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