|
Summary of the current literature published regarding the use of recombinant activated factor VII in trauma |
|||||||
| Ref. (year) |
Patients (n) |
Type of study |
Type of patients |
Dose (μg/kg) |
Reported reduction in transfusion requirements |
Mortality (deaths; n) |
Thrombotic complications |
|
|
|||||||
| [13] (1999) |
1 |
Case report |
Penetrating |
60, 60 |
100% |
0 |
None |
| [12] (2001) |
7 |
Case series |
Blunt and penetrating |
120–212 |
100% |
3 |
None |
| [14] (2002) |
1 |
Case report |
Penetrating |
90 |
100% |
1 |
None |
| [21] (2002) |
19 |
Case series |
Blunt and penetrating |
129 |
78% |
6 |
1 DVT |
| [22] (2002) |
18 |
Case series |
Blunt and penetrating |
40 |
83% |
5 |
1 IAT |
| [17] (2003) |
5 |
Case series |
Blunt and penetrating |
80–144 |
60% |
2 |
None |
| [19] (2003) |
21 |
Case series |
Multi-trauma and surgical |
30–180 |
86% |
5 |
None |
| [20] (2004) |
29 |
Retrospective matched case series |
Blunt and penetrating |
40 |
100% |
11 |
None |
| [32] (2004) |
24 |
Retrospective chart review |
Blunt and penetrating |
? |
100% |
9 |
None |
| [18] (2004) |
81 |
Retrospective cohort |
Blunt and penetrating |
48–148 |
80% |
47 |
None |
| Unpublished (2004) |
277 |
Prospective phase II |
Blunt and penetrating |
200, 100, 100 |
Decreased |
69 |
None |
|
DVT, deep vein thrombosis; IAT, iliac artery thrombosis. | |||||||
Mohr et al. Critical Care 2005 9(Suppl 5):S37 doi:10.1186/cc3784 |
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