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<ui>cc10887</ui>
<ji>1364-8535</ji>
<fm>
<dochead>Poster presentation</dochead>
<bibl>
<title><p>Therapeutic hypothermia in an out-of-hospital arrest population: are we selecting appropriately?</p></title>
<aug>
<au ca="yes" id="A1"><snm>Short</snm><fnm>A</fnm><insr iid="I1"/></au>
<au id="A2"><snm>Brett</snm><fnm>M</fnm><insr iid="I1"/></au>
<au id="A3"><snm>Donaldson</snm><fnm>L</fnm><insr iid="I1"/></au>
</aug>
<insg>
<ins id="I1"><p>Glasgow Royal Infirmary, Glasgow, UK</p></ins>
</insg>
<source>Critical Care</source>


<supplement><title><p>32nd International Symposium on Intensive Care and Emergency Medicine</p></title><note>Meeting abstracts</note></supplement><conference><title><p>32nd International Symposium on Intensive Care and Emergency Medicine</p></title><location>Brussels, Belgium</location><date-range>20-23 March 2012</date-range><url>http://www.intensive.org/</url></conference><issn>1364-8535</issn>
<pubdate>2012</pubdate>
<volume>16</volume>
<issue>Suppl 1</issue>
<fpage>P280</fpage>
<url>http://ccforum.com/content/16/S1/P280</url>
<xrefbib><pubid idtype="doi">10.1186/cc10887</pubid></xrefbib>
</bibl>
<history><pub><date><day>20</day><month>3</month><year>2012</year></date></pub></history>
<cpyrt><year>2012</year><collab>Short et al.; licensee BioMed Central Ltd.</collab><note>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</note></cpyrt>
</fm>
<bdy>
<sec><st><p>Introduction</p></st>
<p>We question how appropriately we select patients to undergo therapeutic hypothermia following out-of-hospital cardiac arrest.</p>
</sec>
<sec><st><p>Methods</p></st>
<p>The population was identified through searching Wardwatcher between August 2006 and February 2011. Inclusion criteria were all patients with an ICU admission of out-of-hospital cardiac arrest. Exclusion criteria were: no CPR within the preceding 24 hours; admission from theatre; insufficient data. Data were gathered from Wardwatcher, Careview and patients' case notes for age, arrest rhythm, downtime (DT) - time from arrest to return of spontaneous circulation, time to initiation of CPR, temperatures at various time points, cause of arrest and outcome. Statistical analysis was performed with Fisher's exact test, significance level of <it>P </it>&lt; 0.05. Permission for use of patient notes was granted from the consultant group of the ICU audited.</p>
</sec>
<sec><st><p>Results</p></st>
<p>Seventy patients had a hospital admission of post-cardiac arrest. Five failed the inclusion criteria and six fulfilled exclusion criteria. A total of 36 (51%) were cooled (Table <tblr tid="T1">1</tblr>). Twelve (33%) of the cooled population survived to hospital discharge (D/C), one (8%) cooled within 4 hours, three (25%) cooled for over 12 hours. Ten (28%) patients were cooled despite not having a cardiac cause. One (4%) of the 23 noncooled patients survived to hospital discharge, four (17%) had a cardiac cause. The median age of cooled population was 66 years (quartile range 53.5 to 74 years) and 44 years (quartile range 41 to 52 years) of the noncooled.</p>
<tbl id="T1"><title><p>Table 1</p></title><caption><p>Population cooled post cardiac arrest</p></caption><tblbdy cols="4">
      <r>
         <c>
            <p/>
         </c>
         <c ca="center">
            <p>
               <b>D/C (<it>n </it>= 12)</b>
            </p>
         </c>
         <c ca="center">
            <p>
               <b>Died (<it>n </it>= 26)</b>
            </p>
         </c>
         <c>
            <p/>
         </c>
      </r>
      <r>
         <c cspan="4">
            <hr/>
         </c>
      </r>
      <r>
         <c ca="left">
            <p>VF arrest</p>
         </c>
         <c ca="center">
            <p>10 (83%)</p>
         </c>
         <c ca="center">
            <p>18 (75%)</p>
         </c>
         <c ca="center">
            <p><it>P </it>= 0.69</p>
         </c>
      </r>
      <r>
         <c ca="left">
            <p>DT &gt;30 minutes</p>
         </c>
         <c ca="center">
            <p>1 (8%)</p>
         </c>
         <c ca="center">
            <p>14 (58%)</p>
         </c>
         <c ca="center">
            <p><it>P </it>= 0.005</p>
         </c>
      </r>
      <r>
         <c ca="left">
            <p>First CPR &lt;5 minutes</p>
         </c>
         <c ca="center">
            <p>11 (92%)</p>
         </c>
         <c ca="center">
            <p>17 (71%)</p>
         </c>
         <c ca="center">
            <p><it>P </it>= 0.22</p>
         </c>
      </r>
      <r>
         <c ca="left">
            <p>Cardiac aetiology</p>
         </c>
         <c ca="center">
            <p>10 (83%)</p>
         </c>
         <c ca="center">
            <p>16 (67%)</p>
         </c>
         <c ca="center">
            <p><it>P </it>= 0.44</p>
         </c>
      </r>
   </tblbdy></tbl>
</sec>
<sec><st><p>Conclusion</p></st>
<p>Survival is improved in patients cooled post-out-of-hospital cardiac arrest <abbrgrp><abbr bid="B1">1</abbr><abbr bid="B2">2</abbr></abbrgrp>. Downtime is statistically significant in the survival of cooled patients. Achieving optimal timing of cooling was no better in surviving versus dying populations. Cooling post-out-of-hospital cardiac arrest is expensive and time-consuming; selection criteria need to be evaluated to concentrate this resource on patients where there is a higher prospect of a positive outcome <abbrgrp><abbr bid="B2">2</abbr></abbrgrp>.</p>
</sec>
</bdy>
<bm>
<refgrp><bibl id="B1"><aug><au><snm>Holzer</snm><fnm>M</fnm></au><etal/></aug><source>Crit Care Med</source><pubdate>2005</pubdate><volume>33</volume><fpage>414</fpage><lpage>418</lpage><xrefbib><pubidlist><pubid idtype="doi">10.1097/01.CCM.0000153410.87750.53</pubid><pubid idtype="pmpid" link="fulltext">15699847</pubid></pubidlist></xrefbib></bibl><bibl id="B2"><aug><au><snm>Hay</snm><fnm>A</fnm></au><etal/></aug><source>Anaesthesia</source><pubdate>2008</pubdate><volume>63</volume><fpage>15</fpage><lpage>19</lpage><xrefbib><pubid idtype="pmpid" link="fulltext">18086065</pubid></xrefbib></bibl></refgrp>
</bm>
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