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<art>
   <ui>cc379</ui>
   <ji>CCJ</ji>
   <fm>
      <dochead>Meeting abstract</dochead>
      <bibl>
         <title>
            <p>The compliance characteristics of the Portex Soft-Seal cuff improves seal against leakage of fluid in a pig trachea model</p>
         </title>
         <aug>
            <au id="A1">
               <snm>Young</snm>
               <fnm>PJ</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A2">
               <snm>Blunt</snm>
               <fnm>MC</fnm>
               <insr iid="I1"/>
            </au>
         </aug>
         <insg>
            <ins id="I1">
               <p>ICU Queen Elizabeth Hospital, Kings Lynn, PE30 4ET, UK</p>
            </ins>
         </insg>
         <source>Critical Care</source>
         <supplement>
            <title>
               <p>19th International Symposium on Intensive Care and Emergency Medicine</p>
            </title>
            <note>Meeting abstracts</note>
         </supplement>
         <conference>
            <title>
               <p>19th International Symposium on Intensive Care and Emergency Medicine</p>
            </title>
            <location>Brussels, Belgium</location>
            <date-range>16&#8211;19 March 1999</date-range>
         </conference>
         <issn>1364-8535</issn>
         <pubdate>1999</pubdate>
         <volume>3</volume>
         <issue>Suppl 1</issue>
         <fpage>P004</fpage>
         <xrefbib>
            <pubid idtype="doi">10.1186/cc379</pubid>
         </xrefbib>
      </bibl>
      <history>
         <pub>
            <date>
               <day>16</day>
               <month>3</month>
               <year>2000</year>
            </date>
         </pub>
      </history>
      <cpyrt>
         <year>1999</year>
         <collab>Current Science Ltd</collab>
      </cpyrt>
   </fm>
   <meta>
      <classifications>
         <classification type="BMC" subtype="old_arx_id">cc-3-s1-p004</classification>
      </classifications>
   </meta>
   <bdy>
      <sec>
         <st>
            <p/>
         </st>
         <p>A high volume low pressure (HVLP) cuff does not protect the lower airway from contamination by material leaking along longitudinal folds within the cuff wall [<abbr bid="B1">1</abbr>]. This is a major factor in the pathogenesis of ventilator associated pneumonia [<abbr bid="B2">2</abbr>]. The combination of shape and high compliance of the Portex Soft-Seal cuff might eliminate the folds in the cuff walls circumferentially for a portion of the cuff and prevent leakage. We have tested the Soft-Seal cuff in a pig trachea model to establish whether protection against leakage is better than that afforded by standard HVLP cuffs.</p>
      </sec>
      <sec>
         <st>
            <p>Method</p>
         </st>
         <p>The Portex Soft-Seal, Mallinckrodt Hi-Lo, Sheridan Preformed and Portex Profile size 8mm internal diameter HVLP cuffed tracheal tubes were assessed for leakage of dye placed in the subglottic space to the trachea in a benchtop ventilation model and in six isolated pig tracheas. All cuffs were inflated at 30 cmH<sub>2</sub>O pressure.</p>
      </sec>
      <sec>
         <st>
            <p>Results</p>
         </st>
         <p>There was no leakage in the ventilation model or in the pig tracheas with the Portex Soft-Seal group, but rapid leakage occurred in all the pig tracheas for the standard HVLP cuffs.</p>
      </sec>
      <sec>
         <st>
            <p>Conclusion</p>
         </st>
         <p>This benchtop study suggests that the improved HVLP cuff compliance characteristics and shape of the Portex Soft-Seal cuff might be beneficial in the prevention of leakage of fluid to the lungs known to occur with HVLP cuffs.</p>
         <tbl id="T1">
            <title>
               <p/>
            </title>
            <caption>
               <p/>
            </caption>
            <tblbdy cols="5">
               <r>
                  <c>
                     <p/>
                  </c>
                  <c>
                     <p/>
                  </c>
                  <c>
                     <p/>
                  </c>
                  <c ca="center">
                     <p>Simulated</p>
                  </c>
                  <c ca="center">
                     <p>Tube</p>
                  </c>
               </r>
               <r>
                  <c>
                     <p/>
                  </c>
                  <c ca="left">
                     <p>Isolated pig</p>
                  </c>
                  <c ca="center">
                     <p>Simulated</p>
                  </c>
                  <c ca="center">
                     <p>tracheal</p>
                  </c>
                  <c ca="center">
                     <p>motion</p>
                  </c>
               </r>
               <r>
                  <c>
                     <p/>
                  </c>
                  <c ca="left">
                     <p>trachea (<it>n</it> = 6)</p>
                  </c>
                  <c ca="center">
                     <p>IPPV</p>
                  </c>
                  <c ca="center">
                     <p>suction</p>
                  </c>
                  <c ca="center">
                     <p>in trachea</p>
                  </c>
               </r>
               <r>
                  <c cspan="5">
                     <hr/>
                  </c>
               </r>
               <r>
                  <c ca="left">
                     <p>Mallinckrodt Hi-lo</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
               </r>
               <r>
                  <c ca="left">
                     <p>Sheridan Preformed</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
               </r>
               <r>
                  <c ca="left">
                     <p>Portex Profile</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
                  <c ca="center">
                     <p>Leak</p>
                  </c>
               </r>
               <r>
                  <c ca="left">
                     <p>Portex Soft-Seal</p>
                  </c>
                  <c ca="center">
                     <p>No leak</p>
                  </c>
                  <c ca="center">
                     <p>No leak</p>
                  </c>
                  <c ca="center">
                     <p>No leak</p>
                  </c>
                  <c ca="center">
                     <p>No leak</p>
                  </c>
               </r>
            </tblbdy>
            <tblfn>
               <p/>
            </tblfn>
         </tbl>
      </sec>
   </bdy>
   <bm>
      <refgrp>
         <bibl id="B1">
            <title>
               <p>Aspiration beyond endotracheal cuffs.</p>
            </title>
            <aug>
               <au>
                  <snm>Seegobin</snm>
                  <fnm>RD</fnm>
               </au>
               <au>
                  <snm>Van Hasselt</snm>
                  <fnm>GL</fnm>
               </au>
            </aug>
            <source>Can Anaes Soc J</source>
            <pubdate>1986</pubdate>
            <volume>33</volume>
            <fpage>273</fpage>
            <lpage>279</lpage>
         </bibl>
         <bibl id="B2">
            <title>
               <p>Prevention of hospital-acquired pneumonia: measuring effect in ounces, pounds, and tons.</p>
            </title>
            <aug>
               <au>
                  <snm>Craven</snm>
                  <fnm>DE</fnm>
               </au>
            </aug>
            <source>Ann Intern Med</source>
            <pubdate>1995</pubdate>
            <volume>122</volume>
            <fpage>229</fpage>
            <lpage>231</lpage>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">7810944</pubid>
            </xrefbib>
         </bibl>
      </refgrp>
   </bm>
</art>
