Image highlight

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Effects of hyperoxia on stretch-induced Akt activation of airway epithelium in Akt mutant mice. Representative photomicrographs (x400) with phosphorylated serine/threonine kinase/protein kinase B (Akt) staining of the lung sections after 5 hours of mechanical ventilation with room air or hyperoxia (n = 6/group). (a) Tidal volume 30 ml/kg wild-type mice with room air. (b) Tidal volume 30 ml/kg wild-type mice with hyperoxia. (c) Tidal volume 30 ml/kg Akt+/- mice with room air. (d) Tidal volume 30 ml/kg Akt+/- mice with hyperoxia. A dark-brown diaminobenzidine signal indicates positive staining of lung epithelium, while lighter shades of bluish tan signify nonreactive cells.

Li et al., Critical Care 2007, 11:R89 [View article]

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