Image highlight

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Burns septic acute renal failure (ARF) group plasma altered polarity, permeability to albumin and nephrin expression on podocytes. (b-d) Representative immunofluorescence images of the altered distribution of the intermediate filament protein nestin in presence of burns septic plasma (d), not detectable after incubation with vehicle alone (b) or control healthy plasma (c) (magnification × 400, nuclei counterstained with 1 µg/ml propidium iodide). After burns septic plasma challenge, nestin lost its typical diffuse distribution and was localized in the sub-membrane spaces forming several "rings" (d). (f-h) Representative immunofluorescence images of the slit diaphragm protein nephrin after exposure to vehicle alone (f), control healthy plasma (g) and burns septic ARF group plasma (h).

Mariano et al., Critical Care 2008, 12:R42 [View article]

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