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Wrong typo in the abstract of the original article leads to a wrong argument in another (Hsiu-Nien Shen, 05 November 2013)

Dear... read full comment

Comment on: et al. Critical Care, 16:R33

Reason for concern (Christian Wiedermann, 03 September 2013)

We had previously noticed the renal replacement therapy (RRT) data listed under "Hemofiltration" in Table 3 of the Critical Care (CC) publication by Boussekey et al. However, only 8 total patients required RRT according to that table compared with a total 82 of patients requiring RRT in the study's entire... read full comment

Comment on: Wiedermann et al. Critical Care, 17:444

Fascinating study which may have more stories to tell (John Pickering, 27 June 2013)

Congratulations to the authors on this fascinating study. We have been waiting a long time for someone to attempt true GFR measurements on AKI patients, not an easy task.... read full comment

Comment on: Bragadottir et al. Critical Care, 17:R108

Paracelsus' wisdom (Giuseppe Citerio, 22 May 2013)

I¿ve read with interest this paper by Schiefecke and others on parenteral Diclofenac infusion in SAH patients..... read full comment

Comment on: Schiefecker et al. Critical Care, 17:R88

BD increase is not always due to shock (Venkatesh Srinivasa, 24 April 2013)

BD value is, when it reflects lactic acidosis. BD can increase during hyperchloremia (hypertonic resuscitation, NS resuscitation) where it is not an indicator of shock. Nonetheless, increased BD from any reason has been shown to have worse outcome. This study emphasizes the need for RCT's. read full comment

Comment on: Mutschler et al. Critical Care, 17:R42

Toothbrushing for preventing ventilator-associated pneumonia: a live issue worth further investigation (Wan-Jie Gu, 07 March 2013)

Reply: We would like to thank Labeau and Blot for their letter and insightful comments.[1] For Critical ill patients with intubation, dental plaque and the oral mucosa can be colonized with potential pathogens associated with ventilator-associated pneumonia (VAP).[2] Observational studies demonstrated that oral care with toothbrushing improved oral hygiene and reduced plaque load.[3,4] Theoretically, toothbrushing may have favorable effect on the development of VAP. However, evidence on this topic still remains limited, which precludes final verdicts and strong clinical recommendations. Moreover, diagnosis is crucial for the prevention of VAP, but debate remains as to the optimal means of diagnosing VAP. In this case, further research on toothbrushing for VAP prevention is warranted. We... read full comment

Comment on: Labeau et al. Critical Care, 17:417

Sad loss -- I will always remember Professor Traber's resonant voice! (Philip M Kober, JD, MD, PhD, 17 December 2012)

I am very saddened to hear of Dr. Dan Traber's death. I am honored to have known him since my days in graduate school in physiology at Loyola University of Chicago. I will always remember his resonant voice -- "Traber, Galveston" -- at American Physiological Society, FASEB, and Shock Society meetings. He will be missed!

Philip M. Kober, JD, MD, PhD read full comment

Comment on: Prough et al. Critical Care, 16:169

Restful organs (Michael Rodgers, 08 November 2012)

Chawla et al make a case for "resting" the kidney. I find this a rather peculiar, non-medical term to use. I presume what they mean is to reduce the metabolism of the... read full comment

Comment on: Chawla et al. Critical Care, 16:317

In patients with sepsis a moderately high PaCO2 may affect cerebral autoregulation and lead to sepsis-associated delirium over time (Patrice Brassard, 05 November 2012)

We are interested in the study by Schramm et al. (1) on a relationship between the incidence of sepsis-associated delirium (SAD) and cerebral autoregulation. Cerebral autoregulation was found impaired one day after the diagnosis of sepsis and several patients developed SAD (after four days). SAD was attributed to the impaired cerebral autoregulation detected on day 1 suggesting that impaired dynamic cerebral autoregulation might trigger SAD. As mentioned by the authors, PaCO2 levels were at the upper normal range and increased from day 1 to 4. We consider that these high PaCO2 levels could have impaired dynamic cerebral autoregulation in these... read full comment

Comment on: Schramm et al. Critical Care, 16:R181

Authors¿ response (Yiyun Lin, 05 November 2012)

We thank Gu for his comments. Indeed, our results indicate that sedation with dexmedetomidine is associated with shorter length of mechanical ventilation and lower risk of delirium following cardiac surgery. Further, dexmedetomidine may decrease the risk of postoperative ventricular tachycardia and hyperglycemia, and not increase length of hospital stay and mortality at hospital discharge. [1] Thus, we hypothesized that dexmedetomidine would be a safe and efficacious sedative agent in cardiac surgical patients.... read full comment

Comment on: Lin et al. Critical Care, 16:R169

A quick thought from a fellow delirium researcher... (Jiten Patel, 22 October 2012)

I was fascinated to read that the simple use of earplugs could impact on patient morbidity during Critical Care Unit... read full comment

Comment on: Van Rompaey et al. Critical Care, 16:R73

Sedation with dexmedetomidine in post-cardiac surgery patients: practical considerations (Wan-Jie Gu, 01 October 2012)

To the... read full comment

Comment on: Lin et al. Critical Care, 16:R169

Probiotics' effects on the incidence of nosocomial pneumonia in critically ill patients: a systematic review and meta-analysis (Yi-Zhen Gong, 26 September 2012)

To the... read full comment

Comment on: Liu et al. Critical Care, 16:R109

Fluid overload after cardiac surgery: too much or the right therapy? (Andrea Rossi Zadra, 26 September 2012)

The work of Stein and colleagues addresses a key issue in cardiac anesthesia and critical care: optimal fluid management may deeply impact on prognosis. The conclusions may suggest cautious intake of fluids to prevent complications, including kidney failure. Despite extensive literature warns against fluid overload, we suggest that correct fluid management should be titrated to reach adequate volemia. After cardiac surgery the question about fluid status may change compared to preoperative conditions: what is now the correct volemia for the patient? Type of surgery, e.g. aortic valve replacement, and inflammation after extracorporeal circulation deeply impact on volume distribution and cardiac preload. Inadequate volemia is associated to poor perfusion and low cardiac output. Thus, the... read full comment

Comment on: Stein et al. Critical Care, 16:R99

Postflight evaluation of inflight emergency cases (Ashok Devkota, 06 June 2012)

To the... read full comment

Comment on: Sand et al. Critical Care, 16:R42

excellent paper (H M, 28 May 2012)

metformin is a uncoupling agent causes uncoupling of oxidative phosphorylation; due to an increase in permeability of the inner mitochondrial membrane, protons heat is generated without atp, (not using ATP synthase ligated channels) reactions involving NADH, FADH increase, H+'s used, generating heat. other uncoupling agents include Salicyates, Alcohol, Dinitrophenol, and of course Metformin. , "SAD-M". Perhaps induced hypothermia would be of benefit in cases with malignant hyperthermia. read full comment

Comment on: Protti et al. Critical Care, 16:R75

Metformin-induced effects in oxygen consumption (Heikki Savolainen, 14 May 2012)

Dear Editor,

The authors of this study have to be congratulated for their elegant experiments and reaching the correct conclusions.

The drug is, in fact, an inhibitor of the complex I in the mitochondrial respiratory chain. This seems to be the main reason for the deleterious effects. Two other circumstances may, however, contribute and aggravate it. D-lactate produced excessively from glucose is slowly metabolized by the D-lactic acid oxidase prolonging the metabolic acidosis, and acidotic excessive protons impair the the terminal cytochrome oxidase which is essentially a proton pump to molecular oxygen.

Thus, metformin interferes with the oxidative phosphorylation at several stages. read full comment

Comment on: Protti et al. Critical Care, 16:R75

Low serum 25(OH)D concentrations may explain the findings regarding IL-6, hyperglycemia and glucose control in septic patients (William B. Grant, 14 May 2012)

The paper by Nakamura et al. [1] reported correlations between interleukin-6 (IL-6) level, hyperglycemia, and glucose control and outcomes of septic patients. Those with failed glucose control had poorer survival rates than those with successful glucose control. Those with failed glucose control had higher IL-6 levels and much higher rates of septic shock.... read full comment

Comment on: Nakamura et al. Critical Care, 16:R58

Steroid timing and the implication for the future septic shock trial (wei huang, 09 March 2012)

Dear editor... read full comment

Comment on: Park et al. Critical Care, 16:R3

units used (Marlène Bouillon, 09 March 2012)

Usually, most experts agree that levels less than 20 ng/ml (50 nmol/L) 25(OH)D are considered deficient and levels between 20 to 30 ng/ml ( 50 to 75 nmol/L) are insufficient, as reported in your references 10-12. It is possible that you make a mistake, since you express all your results as ng/dL ? read full comment

Comment on: Venkatram et al. Critical Care, 15:R292

Study classification within a systematic review of prone ventilation (David Noble, 09 March 2012)

Dear Editor,

I note the study of Mancebo et al has been classified by Abroag et al (Table 1) as one that used "protective lung ventilation".
The study of Mancebo et al commenced in 1998 before "ARDSnet" was published. These authors state that up to 10ml/kg of (actual) body weight and up to 35 or 40cm of water for a plateau pressure was considered acceptable. The accompanying supplement to that paper indicates that even these targets were breached in over 10% of cases.
Can the study of Mancebo et al really be classified as one that used "lung protective ventilation"? read full comment

Comment on: Abroug et al. Critical Care, 15:R6

Glucose and lactate as brain energy sources (Heikki Savolainen, 09 March 2012)

Dear Editor,

This highly significant study shows that insulin administration can diminish cerebral glucose concentration. This effect may be partially ameliorated by the circumstance that L-Lactate can serve as an alternate energy source (1). Furthermore, lactate concentration in blood may rise with the increased intake of glucose in the cells.

Would it not be interesting to follow the cerebral L-lactate metabolism in patients under critical care?

1 Rinholm JE, Hamilton NB, Kessaris N, et al. Regulation of oligodendrocyte development and myelination by glucose and lactate. J Neurosci 2011; 31: 538-548 read full comment

Comment on: Schmidt et al. Critical Care, 16:R15

Importance of Metabolic Acidemia (Viktor Rosival, 03 January 2012)

In the recent study of Jung et al [l] there are some discrepancies with the... read full comment

Comment on: Jung et al. Critical Care, 15:R238

Misconception of Glycemic Control Algorithms (B. Wayne Bequette, 03 January 2012)

Hoekstra and coworkers [1] review the technologies available for computerized glucose regulation in the intensive care unit, but misrepresent the differences between two control algorithms, Proportional-Integral-Derivative (PID) and Model Predictive Control (MPC). The differences between PID and MPC are illustrated by an example of an automobile on a roadway. They claim that the driver using MPC determines his/her driving strategy before departing, and maintains that trajectory throughout the trip. They also claim that the driver using PID makes frequent control action changes based on the difference between the ¿ideal¿ and actual trajectory. The MPC scenario shown is largely incorrect. MPC looks into the future (down the roadway) and determines the best sequence of control actions (driving... read full comment

Comment on: Hoekstra et al. Critical Care, 13:223

typo (Jon Borger, 03 January 2012)

I believe the last sentence of the abstract is still incorrect, despite an apparent previous correction. It should read that SIMV is the "least" effective method of weaning. read full comment

Comment on: Alía et al. Critical Care, 4:72