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Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.

Garnacho-Montero J, Aldabo-Pallas T, Garnacho-Montero C, Cayuela A, Jiménez R, Barroso S, Ortiz-Leyba C.

Crit Care. 2006;10(4):R111.

PMID: 16859504 [PubMed - indexed for MEDLINE]

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Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis.

Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C.

Crit Care Med. 2003 Dec;31(12):2742-51.

PMID: 14668610 [PubMed - indexed for MEDLINE]

Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients.

Nakada TA, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, Watanabe E, Abe R, Hatano M, Tokuhisa T.

J Surg Res. 2005 Dec;129(2):322-8. Epub 2005 Jul 27.

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Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients.

Calvano JE, Um JY, Agnese DM, Hahm SJ, Kumar A, Coyle SM, Calvano SE, Lowry SF.

Surg Infect (Larchmt). 2003 Summer;4(2):163-9.

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Survival analysis of 314 episodes of sepsis in medical intensive care unit in university hospital: impact of intensive care unit performance and antimicrobial therapy.

Degoricija V, Sharma M, Legac A, Gradiser M, Sefer S, Vucicević Z.

Croat Med J. 2006 Jun;47(3):385-97.

PMID: 16758516 [PubMed - indexed for MEDLINE]

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Cytokine gene promoter polymorphisms and mortality in acute renal failure.

Jaber BL, Rao M, Guo D, Balakrishnan VS, Perianayagam MC, Freeman RB, Pereira BJ.

Cytokine. 2004 Mar 7;25(5):212-9.

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Pilot study assessing TNF gene polymorphism as a prognostic marker for disease progression in neonates with sepsis.

Weitkamp JH, Stüber F, Bartmann P.

Infection. 2000 Mar-Apr;28(2):92-6.

PMID: 10782394 [PubMed - indexed for MEDLINE]

Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis.

Oberholzer A, Souza SM, Tschoeke SK, Oberholzer C, Abouhamze A, Pribble JP, Moldawer LL.

Shock. 2005 Jun;23(6):488-93.

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Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism.

Schaaf BM, Boehmke F, Esnaashari H, Seitzer U, Kothe H, Maass M, Zabel P, Dalhoff K.

Am J Respir Crit Care Med. 2003 Aug 15;168(4):476-80. Epub 2003 May 13.

PMID: 12746253 [PubMed - indexed for MEDLINE]

10:

[C-reactive protein concentrations during initial (empiric) treatment of neonatal sepsis]

Janković B, Pasić S, Marković M, Veljković D, Milicić M.

Srp Arh Celok Lek. 2001 May-Jun;129 Suppl 1:17-22. Serbian.

PMID: 15637985 [PubMed - indexed for MEDLINE]

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Community-acquired bacterial meningitis in adults: antibiotic timing in disease course and outcome.

Lepur D, Barsić B.

Infection. 2007 Jun;35(4):225-31. Epub 2007 Jul 23.

PMID: 17646915 [PubMed - indexed for MEDLINE]

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Community-acquired bloodstream infection in critically ill adult patients: impact of shock and inappropriate antibiotic therapy on survival.

Vallés J, Rello J, Ochagavía A, Garnacho J, Alcalá MA.

Chest. 2003 May;123(5):1615-24.

PMID: 12740282 [PubMed - indexed for MEDLINE]

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Timing of drotrecogin alfa (activated) initiation in treatment of severe sepsis: a database cohort study of hospital mortality, length of stay, and costs.

Ernst FR, Johnston JA, Pulgar S, He J, Ball DE, Young JK, Cooper LM.

Curr Med Res Opin. 2007 Jan;23(1):235-44.

PMID: 17207305 [PubMed - indexed for MEDLINE]

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Prevalence of two tumor necrosis factor gene polymorphisms in premature infants with early onset sepsis.

Schueller AC, Heep A, Kattner E, Kroll M, Wisbauer M, Sander J, Bartmann P, Stuber F.

Biol Neonate. 2006;90(4):229-32. Epub 2006 May 29.

PMID: 17108674 [PubMed - indexed for MEDLINE]

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Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis.

Jessen KM, Lindboe SB, Petersen AL, Eugen-Olsen J, Benfield T.

BMC Infect Dis. 2007 Sep 18;7:108.

PMID: 17877801 [PubMed - indexed for MEDLINE]

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Influence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infection.

Barie PS, Hydo LJ, Shou J, Larone DH, Eachempati SR.

Surg Infect (Larchmt). 2005 Spring;6(1):41-54.

PMID: 15865550 [PubMed - indexed for MEDLINE]

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Effect of the LT-alpha (+250 G/A) polymorphism on markers of inflammation and clinical outcome in critically ill patients.

Rauchschwalbe SK, Maseizik T, Mittelkötter U, Schlüter B, Patzig C, Thiede A, Reith HB.

J Trauma. 2004 Apr;56(4):815-22.

PMID: 15187748 [PubMed - indexed for MEDLINE]

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Effects of high-dose of intravenous immunoglobulin and antibiotics on survival for severe sepsis undergoing surgery.

Rodríguez A, Rello J, Neira J, Maskin B, Ceraso D, Vasta L, Palizas F.

Shock. 2005 Apr;23(4):298-304.

PMID: 15803051 [PubMed - indexed for MEDLINE]

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Possible involvement of cytokine gene polymorphisms in fulminant hepatitis.

Takakura M, Tokushige K, Matsushita N, Hashimoto E, Shiratori K.

J Gastroenterol Hepatol. 2007 Aug;22(8):1271-7. Epub 2007 Jun 7.

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TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury.

Barber RC, Aragaki CC, Rivera-Chavez FA, Purdue GF, Hunt JL, Horton JW.

J Med Genet. 2004 Nov;41(11):808-13.

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