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1:

Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial.

Xiao G, Wei J, Yan W, Wang W, Lu Z.

Crit Care. 2008;12(2):R61. Epub 2008 Apr 30.

PMID: 18447940 [PubMed - indexed for MEDLINE]

2:

ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury.

Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, Salomone JP, Dent LL, Harris OA, Ander DS, Lowery DW, Patel MM, Denson DD, Gordon AB, Wald MM, Gupta S, Hoffman SW, Stein DG.

Ann Emerg Med. 2007 Apr;49(4):391-402, 402.e1-2. Epub 2006 Sep 29.

PMID: 17011666 [PubMed - indexed for MEDLINE]

3:

Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial.

Young B, Runge JW, Waxman KS, Harrington T, Wilberger J, Muizelaar JP, Boddy A, Kupiec JW.

JAMA. 1996 Aug 21;276(7):538-43.

PMID: 8709402 [PubMed - indexed for MEDLINE]

4:

The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial.

Mosenthal AC, Livingston DH, Lavery RF, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R.

J Trauma. 2004 May;56(5):1042-8.

PMID: 15179244 [PubMed - indexed for MEDLINE]

5:

Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group.

Marmarou A, Nichols J, Burgess J, Newell D, Troha J, Burnham D, Pitts L.

J Neurotrauma. 1999 Jun;16(6):431-44.

PMID: 10391361 [PubMed - indexed for MEDLINE]

6:

Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial.

Livingston DH, Lavery RF, Mosenthal AC, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R.

J Trauma. 2005 Dec;59(6):1298-304; discussion 1304.

PMID: 16394900 [PubMed - indexed for MEDLINE]

7:

Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial.

Maas AI, Murray G, Henney H 3rd, Kassem N, Legrand V, Mangelus M, Muizelaar JP, Stocchetti N, Knoller N; Pharmos TBI investigators.

Lancet Neurol. 2006 Jan;5(1):38-45.

PMID: 16361021 [PubMed - indexed for MEDLINE]

8:

Dosing and safety of cyclosporine in patients with severe brain injury.

Hatton J, Rosbolt B, Empey P, Kryscio R, Young B.

J Neurosurg. 2008 Oct;109(4):699-707.

PMID: 18826358 [PubMed - indexed for MEDLINE]

9:

The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury.

Holland MC, Mackersie RC, Morabito D, Campbell AR, Kivett VA, Patel R, Erickson VR, Pittet JF.

J Trauma. 2003 Jul;55(1):106-11.

PMID: 12855888 [PubMed - indexed for MEDLINE]

10:

A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.

Marshall LF, Maas AI, Marshall SB, Bricolo A, Fearnside M, Iannotti F, Klauber MR, Lagarrigue J, Lobato R, Persson L, Pickard JD, Piek J, Servadei F, Wellis GN, Morris GF, Means ED, Musch B.

J Neurosurg. 1998 Oct;89(4):519-25.

PMID: 9761043 [PubMed - indexed for MEDLINE]

11:

Neuroprotective effect of gacyclidine. A multicenter double-blind pilot trial in patients with acute traumatic brain injury.

Lepeintre JF, D'Arbigny P, Mathé JF, Vigué B, Loubert G, Delcour J, Kempf C, Tadié M.

Neurochirurgie. 2004 Jun;50(2-3 Pt 1):83-95.

PMID: 15213636 [PubMed - indexed for MEDLINE]

12:

Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial.

Meythaler JM, Brunner RC, Johnson A, Novack TA.

J Head Trauma Rehabil. 2002 Aug;17(4):300-13.

PMID: 12105999 [PubMed - indexed for MEDLINE]

13:

Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury.

Natale JE, Guerguerian AM, Joseph JG, McCarter R, Shao C, Slomine B, Christensen J, Johnston MV, Shaffner DH.

Pediatr Crit Care Med. 2007 Jan;8(1):1-9.

PMID: 17251875 [PubMed - indexed for MEDLINE]

14:

Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial.

Knoller N, Levi L, Shoshan I, Reichenthal E, Razon N, Rappaport ZH, Biegon A.

Crit Care Med. 2002 Mar;30(3):548-54.

PMID: 11990913 [PubMed - indexed for MEDLINE]

15:

Survival and functional outcome of children requiring endotracheal intubation during therapy for severe traumatic brain injury.

Thakker JC, Splaingard M, Zhu J, Babel K, Bresnahan J, Havens PL.

Crit Care Med. 1997 Aug;25(8):1396-401.

PMID: 9267956 [PubMed - indexed for MEDLINE]

16:

"Ultrahigh" dexamethasone in acute brain injury. Results from a prospective randomized double-blind multicenter trial (GUDHIS). German Ultrahigh Dexamethasone Head Injury Study Group.

Gaab MR, Trost HA, Alcantara A, Karimi-Nejad A, Moskopp D, Schultheiss R, Bock WJ, Piek J, Klinge H, Scheil F, et al.

Zentralbl Neurochir. 1994;55(3):135-43.

PMID: 7810251 [PubMed - indexed for MEDLINE]

17:

Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial.

Temkin NR, Anderson GD, Winn HR, Ellenbogen RG, Britz GW, Schuster J, Lucas T, Newell DW, Mansfield PN, Machamer JE, Barber J, Dikmen SS.

Lancet Neurol. 2007 Jan;6(1):29-38.

PMID: 17166799 [PubMed - indexed for MEDLINE]

18:

Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group.

Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H.

Stroke. 1998 Jan;29(1):12-7.

PMID: 9445321 [PubMed - indexed for MEDLINE]

19:

Regional differences in patient characteristics, case management, and outcomes in traumatic brain injury: experience from the tirilazad trials.

Hukkelhoven CW, Steyerberg EW, Farace E, Habbema JD, Marshall LF, Maas AI.

J Neurosurg. 2002 Sep;97(3):549-57.

PMID: 12296638 [PubMed - indexed for MEDLINE]

20:

Reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale: a measure of the use of intracranial pressure-directed therapies.

Shore PM, Hand LL, Roy L, Trivedi P, Kochanek PM, Adelson PD.

Crit Care Med. 2006 Jul;34(7):1981-7.

PMID: 16691131 [PubMed - indexed for MEDLINE]

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