Clinical biomarkers
Collection published: 22 September 2011
Last updated: 19 April 2012
With the increasing sophistication of diagnostic processes and expanding
knowledge about association between biomolecules, genomics and acute
disease, interest in biomarkers is at an all time high. Although there are
many research studies into validating and understanding the prognostic
and diagnostic value of biomarkers, this remains a relatively young field
in terms of actual translation to the clinic.
This thematic series covers recent advances in the clinical applications
of biomarkers across a range of medically-relevant topics, demonstrating
that biomarkers for acute illness are moving into the mainstream clinic
but also highlighting the work that still lies ahead to make them more
clinically useful.
We are now seeking submissions of original research offering novel insights
into the clinical utility of biomarkers in disease, to be published in BMC Medicine
and presented as part of this ongoing thematic series. If you would like
your work to be considered, please send a presubmission enquiry to
bmcmedicineeditorial@biomedcentral.com.
|
|
|
Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery
Ioannis Prassas, Caitlin C Chrystoja, Shalini Makawita, Eleftherios P Diamandis BMC Medicine 2012, 10:39 (19 April 2012)
Abstract | Provisional PDF
| PubMed
|
Editor’s summary
A novel bioinformatics strategy that mines publicly available databases identifies tissue-specific proteins that are candidates for cancer serum biomarkers, overcoming the limitations of current biomarkers, which lack tissue specificity.
|
|
|
|
The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department
Christian H Nickel, Roland Bingisser, Nils G Morgenthaler BMC Medicine 2012, 10:7 (20 January 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Morgenthaler and colleagues review the recent progress in determining the prognostic and diagnostic value of copeptin, which is released in response to stress, as a biomarker for risk stratification in the emergency department.
|
|
|
|
Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer
Robert S Phillips, Ros Wade, Thomas Lehrnbecher, Lesley A Stewart, Alex J Sutton BMC Medicine 2012, 10:6 (18 January 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Evidence from a systematic review and meta-analysis suggests inconclusive predictive value of serum biomarkers for pediatric febrile neutropenic episodes, but further studies for the roles of IL6, IL8 and procalcitonin should be conducted.
|
|
|
|
suPAR as a prognostic biomarker in sepsis
Katia Donadello, Sabino Scolletta, Cecilia Covajes, Jean-Louis Vincent BMC Medicine 2012, 10:2 (5 January 2012)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Donadello and colleagues review the clinical utility of suPAR as a biomarker for sepsis, and discuss how it can be used to monitor response to treatment in critically ill patients.
|
|
|
|
Peroxiredoxin 4: a multifunctional biomarker worthy of further exploration
Janin Schulte BMC Medicine 2011, 9:137 (23 December 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
In our latest article in the Clinical Biomarkers series, Janin Schulte comments on the enzyme peroxiredoxin 4, an indicator of altered redox environment in acute and chronic infections, and highlights the multiple uses of this enzyme as a prognostic biomarker.
|
|
|
|
Acute kidney injury biomarkers: renal angina and the need for a renal troponin I
Stuart L Goldstein BMC Medicine 2011, 9:135 (21 December 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Novel biomarkers can be used for prognosis of acute kidney injury (AKI), and in our latest addition to the Clinical Biomarkers series, Stuart L Goldstein discusses the importance of such biomarkers in early detection of AKI.
|
|
|
|
Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
Jorja D Warren, Wei Xiong, Ashley M Bunker, Cecily P Vaughn, Larissa V Furtado, William L Roberts, John C Fang, Wade S Samowitz, Karen A Heichman BMC Medicine 2011, 9:133 (14 December 2011)
Abstract | Full text | PDF | PubMed |
|
Editor’s summary
The biomarker septin 9 methylated DNA, which can be detected in blood plasma, provides a promising diagnostic test for colorectal cancer (CRC) of all stages, and can be used to screen for CRC in patients unable to undergo colonoscopy.
|
|
|
|
Biomarkers of acute lung injury: worth their salt?
Alastair G Proudfoot, Matthew Hind, Mark JD Griffiths BMC Medicine 2011, 9:132 (12 December 2011)
Abstract | Full text | PDF | PubMed
|
Editor’s summary
Griffiths and colleagues discuss the role of biomarkers in the management of acute lung injury, a life-threatening form of hypoxemic respiratory failure, and critically examine the current strategies used to identify biomarkers.
|
|
|
|
Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future
Philipp Schuetz, Werner Albrich, Beat Mueller BMC Medicine 2011, 9:107 (22 September 2011)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
|
Editor’s summary
Mueller and colleagues kick off our new thematic series on Clinical Biomarkers with a review on the utility of procalcitonin in the diagnosis of bacterial infection and decisions about antibiotic treatment in different clinical settings.
|
